This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) provides $2,309,934 in funding to elucidate the role of brain aromatase in the development of Alzheimer's disease (AD) and identify whether aromatase is a target for pulsed photobiomodulation (PBM) therapy to prevent and manage AD. The 5-year project aims to: 1) examine whether downregulation or...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,000 to Northeastern University to develop and apply new intravital microscopy techniques to study the effects of gamma entrainment, a non-pharmacological neuromodulation technique, on cerebral energy metabolism and microvascular hemodynamics in Alzheimer's disease models. The overarching goal is to gain a deeper understanding of how this gamma entrainment method influences brain function,...
This federal Project Grant award, totaling $2,283,334, was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The award was granted to the Morehouse School of Medicine (MSM) to develop and validate a progressive murine model for traumatic brain injury (TBI)-induced Alzheimer's disease and related dementias (TBI-ADRD). The key objectives of this 5-year project are to: 1) Screen diverse mouse strains and TBI injury models to identify the optimal...
This National Institute on Aging (NIA) Project Grant award under the Aging Research federal grant program (CFDA 93.866) will support research to investigate the role of mitochondrial dysfunction in the development of Alzheimer's disease-like pathology following traumatic brain injury (TBI). The $158,247 award, covering the period from August 1, 2024 to July 31, 2027, will fund a project at the University of Cincinnati that aims to characterize cell-specific changes in mitochondrial bioenergetics...
This $1,193,500 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms by which transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) modulate cerebral microvascular function and its influence on neuronal activity. The Lovelace Biomedical Research Institute will conduct in-vivo studies using awake multiphoton microscopy to assess changes in microvascular tone,...
This federal Project Grant award, valued at $6,226,692.00 and funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to track early electrophysiological changes in the locus coeruleus (LC) and hippocampus (HPC) as key brain regions impacted by the accumulation of beta-amyloid and tau proteins. The research seeks to understand...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,109,079 to the Regents of the University of California at Riverside to model the role of age at traumatic brain injury (TBI) in the development of Alzheimer's disease and related dementias (ADRD). The research aims to examine how ADRD risk factors like APOE and amyloid-beta accelerate ADRD progression in a closed head injury TBI mouse model over the animal's lifespan. The study will...
This federal Project Grant award of $2,217,454.00, awarded by the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420), supports a research study on the effects of transcranial photobiomodulation (PBM) in older adults with traumatic brain injury. The primary awardee is the Research Foundation of the City University of New York, which is collaborating with New York University School of Medicine as a sub-grantee. The research aims to...
This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...