This $717,709 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to advance the understanding of tau protein aggregation and propagation in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The awardee, Weill Medical College of Cornell University, will utilize advanced proteomic techniques, including affinity purification mass spectrometry and transcriptomic profiling, to map the molecular mechanisms underlying tau pathology in...
This $2,190,943 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a comprehensive study to examine the relationship between tau protein deposition and functional brain network health in older adults with normal cognition. The researchers at the University of Alabama at Birmingham will use tau PET imaging and resting-state fMRI to investigate how tau pathology affects brain network segregation, dynamics, and cortical atrophy. The study aims...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,592,854 in funding to the University of Illinois to conduct research on tau protein conformation and its role in neurodegenerative diseases like Alzheimer's disease. The key objectives are to: 1) define the effects of tau post-translational modifications on tau function and pathology, 2) determine the role of disease-related tau forms in sporadic and inherited tauopathies, 3) identify...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $437,250 to the University of California, San Diego (UCSD) to develop new imaging tools to study the form and function of tau protein, which is associated with Alzheimer's disease. The award will fund the creation of a peptide-based probe that uses aggregation-induced emission (AIE) to directly measure tau protein as it transitions from a soluble state to liquid-liquid phase separation...
This $757,027 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the mechanisms underlying the synergistic relationship between tau and TDP-43 proteins in the pathophysiology of Alzheimer's disease (AD). The primary awardee, the University of Washington, will use a C. elegans model to interrogate how the combined presence of tau and TDP-43 pathology impairs the lysosomal autophagy pathway, a key compensatory mechanism...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $459,076 to investigate the early transcriptional and pathological changes in vulnerable brain regions during the prodromal stages of Alzheimer's disease (AD). The primary awardee, Trustees of Boston University, will use single-nucleus RNA sequencing and targeted mass spectrometry to profile cell types and tau proteoforms in the transentorhinal cortex, entorhinal cortex, and prefrontal cortex of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,118,700.00 to New York University School of Medicine to conduct research on the disruption of endosomal microautophagy (EMI) by pathological tau protein, a key feature of Alzheimer's disease. The research aims to elucidate the role of tau in destabilizing EMI through mitochondrial disruption and changes to EMI pathway components. Experiments will manipulate EMI components to determine...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $594,041 to the University of Southern California to conduct research on the impact of ethnicity on the utility of plasma amyloid and tau biomarkers to predict Alzheimer's disease. The project aims to comprehensively measure phosphorylated tau species (p-tau217) in plasma samples from the Health and Aging Brain Study-Health Disparities (HABS-HD) cohort, which includes Hispanic,...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a $773,816 research initiative at the University of California, Irvine to investigate the molecular mechanisms of misfolded protein accumulation in Alzheimer's disease-related tauopathies. The 5-year project, which commenced on June 1, 2025, aims to create cell-type-specific atlases of misprocessed and aberrant RNAs and proteins in mouse models and human brains. Key research...
This federal Project Grant award of $1,711,908 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a study by the University of California, San Francisco (UCSF) to evaluate the association between depressive symptoms, cortico-limbic tau, and cognitive decline in individuals with mild cognitive impairment (MCI). The 5-year study aims to: 1) assess the relationship between depressive symptoms and tau binding in the brain; 2) clarify the relative associations of depression,...