This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $302,960 to Harvard T.H. Chan School of Public Health to conduct research on identifying individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those at risk of serious adverse events. The research will utilize advanced statistical methods and pooled data from multiple large-scale randomized trials to detect...
This $4,517,210 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study by Tulane University to examine the relationship between reproductive history, lifetime metabolic exposures, and midlife cognition and brain function. The three-year project aims to: 1) assess reproductive history as a predictor of midlife cognition and cognitive decline; 2) examine reproductive history as a predictor of brain structural and functional outcomes;...
This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $715,801 to Duke University to investigate the causal role of blood-brain barrier dysfunction and neuroinflammation in exacerbating postoperative delirium and subsequent onset of Alzheimer's disease and related dementias in aging and hypertension. The overarching goal is to elucidate how hypertension primes the neurovascular unit and worsens delirium-like behavior after orthopedic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support Emory University's research into the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The $528,876 award, effective June 1, 2025, will fund the development of new analytic tools to integrate genomic data across multiple tissues and improve the identification of genetic risk factors and underlying molecular mechanisms for...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a $2,466,305 study to investigate the association between hypertension, hypertension treatment targets, and the risk of Alzheimer's disease and related dementias (ADRD) among a nationally representative sample of 1.4M U.S. veterans. The study aims to: 1) estimate the association between hypertension and ADRD risk, overall and within subgroups defined by race/ethnicity, region, and...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research provides $1,532,721 in funding to the University of Delaware to conduct a 3-year longitudinal study on the impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive aging. The study aims to determine the early mechanisms linking vascular risk factors with the loss of brain tissue structure and function, including examining the spatial and temporal relationships between...
This $6.18 million project grant from the National Institutes of Health's National Institute on Aging will fund the University of Texas at Austin to conduct the first large-scale genomic analysis of continuous rates of longitudinal aging-related cognitive change prior to dementia onset. Working with sub-awardees the University of Colorado and the University of Edinburgh, the researchers will identify genetic variants beyond APOE that confer risk for cognitive decline leading to eventual...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), is supporting research to characterize microvascular impairment in adults with elevated genetic risk for Alzheimer's disease. The $831,583 award, which runs from March 2025 to January 2030, will be used by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate physiological mechanisms through which the APOE-E4 gene contributes to...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $640,906 to the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The project aims to utilize advanced neuroimaging techniques to characterize the impact of vascular disease processes, including vascular stiffness and decreased flow tone, on brain tissue integrity and cognition in the presence...
This Project Grant award of $794,978.00 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support a longitudinal study to examine accelerated epigenetic aging as a mechanism linking socioeconomic disadvantage across the lifespan to cognitive decline in midlife. The research will leverage the Adult Health and Behavior Project's existing data on individual socioeconomic status, neuropsychological assessments, and stored blood samples to analyze...