Project Grant R01AG084710

Award Date 9/1/24
Completion Date 4/30/29
Dollars Obligated $1.1M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $805,295 to The Leland Stanford Junior University to conduct a 5-year study examining cerebrospinal fluid (CSF) and blood biomarkers to gain insight into postoperative delirium and neurocognitive dysfunction. The key objectives are to: Determine if CSF biomarkers of baseline risk, blood-brain barrier injury, inflammation, neuronal injury, and astrocyte injury/astrocytosis are associated with...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $813,123 to The General Hospital Corporation Research Management Division (Massachusetts General Hospital) to investigate the role of perineuronal nets (PNNs), a component of the extracellular matrix, in the development of postoperative delirium (POD) in older adults. The project aims to: 1) examine the kinetics of neuroinflammation-mediated PNN degradation after anesthesia and...
The National Institute on Aging (NIA) awarded a $2,356,117 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University to study the usage of novel linked databases to improve the perioperative management of patients with Alzheimer's disease and related dementias. The project aims to: (a) identify the extent to which surgical patients with Alzheimer's disease and related dementias (ADRD) are at increased risk for adverse postoperative outcomes, and (b) estimate the...
This $3,506,058 project grant award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), supports a study to evaluate the efficacy of nighttime intravenous and sublingual dexmedetomidine in preventing postoperative delirium (POD) and improving cognitive outcomes in elderly patients following cardiac surgery. The primary awardee is The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). As part of the study, MGH has sub-awarded portions of...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) aims to investigate the role of perineuronal nets (PNN) in the development of postoperative delirium in aged mice. The $161,500 award, effective July 15, 2024 through June 30, 2026, will fund research to determine if changes in PNN quantity and composition coincide with delirium-like cognitive impairment in aged mice following exposure to anesthesia, surgery, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $121,550 to The Leland Stanford Junior University (Stanford University) to conduct research on the structural determinants of healthy aging. The key products and services to be delivered under this grant include: Assessing the role of governmental spending priorities in early life on mid-life cognition, later-life dementia risk, and racial inequity therein. The research aims to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,342,815 will fund a study entitled "Delirium Dynamics: Understanding Causes and Effects" at Northwestern University. The research project aims to apply novel continuous monitoring techniques to investigate how specific disturbances in sleep-wake activity and circadian rhythms impact the acute fluctuations and long-term cognitive outcomes of delirium in...
This federal Project Grant award from the National Institutes of Health (CFDA 93.279 - Drug Abuse and Addiction Research Programs) provides $1,105,489 to The Leland Stanford Junior University (Stanford University) to fund research aimed at reducing the risk of persistent postoperative opioid use and opioid use disorder among older adults undergoing inpatient surgery. The key products and services to be delivered under this 2-year grant include: Augmenting an existing dataset that links...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $506,404 will fund research at the University of Pennsylvania to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key focus areas include: Deciphering how enhancer communities or "cliques" are formed and the major transcription factors that drive their formation during senescence and...
The National Institute on Aging (NIA) awarded a $444,125 Project Grant (CFDA 93.866 - Aging Research) to the University of Virginia (UVA) to study the use of exhaled volatile organic compounds (VOCs) and Alzheimer's disease (AD)-related blood biomarkers to predict postoperative delirium (POD) in elderly patients undergoing spine surgery. The research aims to determine if a non-invasive analysis of exhaled VOCs can be used to predict POD, and to investigate the relationship between exhaled...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,137,836 to The Leland Stanford Junior University to investigate the role of epigenetics in the pathogenesis of post-operative delirium (POD) and its relationship to long-term cognitive decline in elderly dementia patients.

The objective is to identify potential epigenetic biomarkers, specifically DNA methylation changes, that could predict the risk of POD and subsequent patient outcomes such as post-operative cognitive decline and dementia. The research will follow a large sample of elderly patients undergoing hip fracture surgery, comparing genome-wide DNA methylation profiles between those who develop POD and those who do not. This work aims to enhance the understanding of epigenetic mechanisms underlying delirium and its interplay with dementia progression, potentially leading to improved medical and surgical practices.

The project includes a $258,963 sub-award to Vanderbilt University Medical Center to provide specialized expertise and access to patient cohorts for the epigenetics research.

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