Project Grant R01AG084707

Award Date 7/15/24
Completion Date 6/30/29
Dollars Obligated $1.6M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Rochester, NY 14642, USA
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This Project Grant award of $1,905,716.00 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research conducted by New York University School of Medicine to study the aging skeletal stem cell niche. The research aims to elucidate the molecular mechanisms regulating the inflammatory response in skeletal stem and progenitor cells (SSPCs) and the role of anti-inflammatory factors in resolving inflammation. By investigating how these pro- and anti-inflammatory...
The National Institute on Aging (NIA) awarded a $2,541,656 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic to characterize senescent cell populations in skeletal aging. The grant aims to leverage novel mouse models and single-cell analysis techniques to better define the mechanisms driving cellular senescence in the bone microenvironment and identify key senescent cell populations that contribute to skeletal aging. As part of the grant, the University of Connecticut Health Center...
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The key objectives are to fully characterize the detrimental subsets of senescent cells in bone fracture callus and examine how they impair fracture repair in aged mice. The research will investigate the underlying mechanisms, including how senescent cells regulate PDGFRB signaling and cell proliferation in mesenchymal progenitor cells via TGF-β1 and TIMP2. The findings aim to identify novel drug targets and interventions to enhance fracture healing in the elderly, who face high morbidity and mortality from bone fractures. The project will run from July 2024 through June 2029.

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