Project Grant R01AG084624

Award Date 9/1/24
Completion Date 5/31/29
Dollars Obligated $821K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Boston, MA 02118, USA
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This federal Project Grant award in the amount of $820,553, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to study long non-coding RNAs (lncRNAs) as potential therapeutic targets and biomarkers for Alzheimer's disease and related dementias. The grant will fund research to:

  1. Analyze lncRNA expression patterns in postmortem brain samples from individuals with Alzheimer's, frontotemporal dementia, and healthy controls to identify disease-associated lncRNAs.

  2. Determine the functions of candidate lncRNA biomarkers in relevant in vitro and in vivo models.

  3. Evaluate the potential of lncRNA biomarker candidates to differentiate between cognitively normal elderly adults, those with mild cognitive impairment, and dementia patients in plasma samples from major longitudinal studies.

The project involves collaboration between the lead awardee, Trustees of Boston University, and sub-awardees at the German Center for Neurodegenerative Diseases, University of Massachusetts Medical School, and Indiana University, who will contribute expertise in lncRNA analysis, biostatistics, clinical research, and neuroimaging.

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