Project Grant R01AG085793
- The National Institute on Aging (NIA) awarded a $157,998 Project Grant to The Medical University of South Carolina (MUSC) on July 17, 2025 under the Aging Research federal grant program (CFDA 93.866). The grant supports research to investigate the role of ceramides, a class of bioactive lipids, in regulating mitophagy (the recycling of damaged mitochondria) and its potential therapeutic applications for Alzheimer's disease. The research aims to elucidate the intricate mechanisms by which...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $156,512 project grant to the Regents of the University of Minnesota, to be completed by September 29, 2025. The grant will support research investigating the role of lipid aldehydes in inducing cellular senescence in adipose tissue, a key factor in age-related metabolic dysfunction. The proposed studies aim to characterize the biochemistry and signaling mechanisms underlying this...
- The University of Southern California received a $126,042 project grant from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), to investigate the role of mitochondrial proline catabolism, specifically the ALH-6 gene, in muscle-mitochondrial dynamics and their impact on health and longevity. This research builds upon previous studies in C. elegans that have linked ALH-6 mutations to premature aging, impaired muscle function, and mitochondrial...
- The National Institute on Aging (NIA) awarded a $354,000 Project Grant under the Aging Research program (CFDA 93.866) to Panorama Research Incorporated, a for-profit biotech company in Sunnyvale, CA. The grant supports research to develop a novel therapy for sarcopenia, characterized by age-related loss of skeletal muscle mass, quality, and strength. The proposed therapy is based on the adipokine Isthmin 1 (ISM1), which has been shown to promote protein synthesis and suppress degradation...
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $461,313 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Yale University. The funding supports a 2-year research project to investigate the role of the protein CSPalpha in regulating presynaptic autophagy and neurodegeneration. Key objectives include characterizing synaptic vesicles and autophagosomes in wild-type and CSPalpha knockout mouse models, as well...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This $1,044,855 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund Nemalife Inc. to deliver high-throughput testing of anti-aging and FDA-approved drugs in genetically diverse invertebrate Alzheimer's disease models. Under the Aging Research program (CFDA 93.866), the awardee will screen 300 anti-aging compounds and 200 FDA drugs to identify candidates that improve neuronal aging and protect against protein misfolding diseases...
- The National Institute on Aging (NIA) awarded a $785,348 project grant (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies in La Jolla, California. The project, titled "Chronic Sleep Disruption is a Stressor for Healthspan and Lifespan", will investigate the biological mechanisms by which chronic sleep disruption (CSD) may interact with the aging process to increase the risk of age-related diseases. The research aims to determine if long-term CSD affects the...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a 5-year, $753,728 Project Grant (R01AG085793) to the University of Alabama at Birmingham (UAB) to investigate the role of ceramide signaling in regulating healthspan and lifespan in mouse models. The study aims to determine the association between growth hormone deficiency, altered lipid profiles, and longevity, with a focus on the implications of ceramides in aging-related processes such as insulin resistance, mitochondrial dysfunction, inflammation, and cellular senescence. The research approach integrates the understanding of growth hormone action and ceramide signaling from the cellular to whole-animal level, with the goal of developing potential translational interventions. Additionally, the University of Utah received a sub-award under this grant to support the research on targeting ceramide signaling to enhance healthy aging and combat tauopathy in mammals.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $753.7k | 11/22/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
000544246SC001SUNS | University Of Utah | Project Grant R01AG085793 | $376.4k | 1/12/25 |