Project Grant R01AG083949

Award Date 5/15/24
Completion Date 1/31/29
Dollars Obligated $2.1M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
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This $1,118,700.00 federal Project Grant award issued by the National Institute on Aging (CFDA 93.866 Aging Research) supports research at New York University (NYU) School of Medicine to investigate the disruption of endosomal microautophagy (EMI) by pathological tau protein. The research aims to elucidate the role of tau in destabilizing EMI, a key protein degradation pathway, and determine which EMI components are most vulnerable to tau pathology. Experiments will use human-derived neural...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $320,000 to the University of Texas Medical Branch at Galveston to conduct research on the role of tau protein and alternative polyadenylation (APA) in Alzheimer's disease. The study aims to comprehensively profile APA transcripts and gene expression in neurons expressing wild-type and mutant tau proteins, with the goal of better understanding how tau oligomerization impacts APA and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Arizona State University provides $431,750 in funding to conduct research on the role of tau protein proteolysis in Alzheimer's disease. The key objectives are to: 1) test and rank the ability of tau protein peptide fragments generated by proteolysis to induce the aggregation of full-length tau protein, and 2) characterize the intracellular signaling activity of these tau peptides. Using...
This National Institute on Aging Federal Grant Award under the Aging Research program (CFDA 93.866) provides $385,000.00 to Wayne State University to investigate the role of local protein synthesis in tau pathology and neurodegeneration related to Alzheimer's disease. The project aims to determine how pathogenic forms of the tau protein specifically interfere with dendritic protein synthesis, which may contribute to the synaptic dysfunction observed in Alzheimer's disease. By leveraging tau...
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The National Institute on Aging (NIA) awarded a $7,249,563 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of California, San Francisco (UCSF). This 3-year award, starting on Aug 1, 2023, will support research to characterize the structural properties and variability of tau protein aggregation in different brain cell types and at different disease stages of Alzheimer's and related dementias (ADRD). The project aims to develop new...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $267,310 to the University of Washington to conduct research investigating the role of the endoplasmic reticulum unfolded protein response in tauopathy, which is associated with Alzheimer's disease. The project aims to leverage genetic approaches in C. elegans to identify molecular mechanisms in the unfolded protein response that may modulate tauopathy, as well as determine the role of...
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This $2,061,909 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Weill Medical College of Cornell University supports research on tau proteostasis and chaperone complexes in tauopathies, including Alzheimer's disease. The objective is to identify molecular mechanisms regulating tau aggregation and neurodegeneration, specifically examining how two chaperone complexes - the "foldase" complex that stabilizes tau and the "degradase" complex that targets tau for degradation - affect tau pathology. The research will be conducted in vitro, in primary neurons, and in mouse models, with the goal of revealing new therapeutic targets for treating tauopathies. The award period is from May 15, 2024 to January 31, 2029.

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