Project Grant R01AG082685

Award Date 9/30/24
Completion Date 7/31/29
Dollars Obligated $1.2M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Boston, MA 02115, USA
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This $2,366,213 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund the INLIFE (Individualized Lifestyle Change for Every Aging Brain) study. The study aims to harmonize and analyze participant-level data from 12 U.S. randomized controlled trials to examine how changes in lifestyle behaviors such as physical activity, cognitive activity, diet, and social engagement impact cognitive outcomes across diverse older adult populations....
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
The National Institute on Aging (NIA) awarded a Project Grant totaling $2,283,522 to Harvard T.H. Chan School of Public Health on September 17, 2024 under the NIA's Aging Research Federal Grant Program (CFDA 93.866). This 3-year project aims to evaluate the impact of a new Centers for Medicare and Medicaid Services (CMS) policy, the "80% Rule," on enrollment changes of Medicare-Medicaid dual eligible beneficiaries from non-integrated "look-alike" plans into integrated care...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $158,918 to Vanderbilt University to conduct a multi-omic study exploring the impact of lifestyle variation on immunological aging patterns. The study will focus on characterizing age-associated molecular phenotypes such as gene expression, DNA methylation, and clonal hematopoiesis in peripheral blood samples collected from subsistence-level populations (Tsimane, Turkana, Orang Asli) and a...
This $312,900 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research to identify the genetic basis of extraordinary lifespan in a model organism, the nematode Caenorhabditis elegans. The 5-year project aims to: (1) discover the genetic variants responsible for longevity in a naturally occurring long-lived C. elegans isolate, (2) analyze how natural variation affects lifespan and develop tissue-specific "aging...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,085,789 to the Albert Einstein College of Medicine to investigate the relationship between clonal hematopoiesis (CH), aging, and exceptional longevity. The key objectives are to: Determine the prevalence and mutational spectrum of CH, and its association with age-related diseases, in populations with exceptional longevity (centenarians and their offspring). Analyze longitudinal changes in...
This federal Project Grant award for $729,567, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a study to investigate the causal impacts of two key childhood environmental conditions - school quality and infectious disease exposure - on adult health and mortality outcomes. The study aims to construct a novel dataset linking individual-level childhood environment factors to longevity, in order to examine how these modifiable conditions affect schooling,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The University of Texas Health Science Center at San Antonio is focused on investigating the impact of leptin modulation on healthspan and lifespan. The award, totaling $1,339,916 and spanning from September 2024 to July 2029, will assess whether aging-associated hyperleptinemia accelerates cellular senescence and impairs healthspan and lifespan, evaluate the effects of reducing leptin on cellular...
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The National Institute on Aging (NIA) awarded a $1,244,902 Project Grant under the Aging Research program (CFDA 93.866) to Harvard T.H. Chan School of Public Health, with a start date of September 30, 2024 and an ultimate completion date of July 31, 2029. The grant, titled "Lifestyle Factors and Longevity (LIFELONG) Study", aims to evaluate the impact of dietary and other modifiable factors on the likelihood of older adults achieving exceptional longevity (living to age 90).

The study will leverage a consortium of 11 large, well-characterized prospective cohorts worldwide, with nearly 317,000 participants aged 60-75 years, including over 31,000 individuals who lived to age 90. The research will examine the associations between commonly consumed foods, dietary fiber, food group diversity, adherence to planetary health diets, and lifestyle scores with exceptional longevity, accounting for potential modifying effects of sociodemographic, behavioral, and health factors. Columbia University is a sub-grantee and will provide scientific contributions to the analyses around dietary and lifestyle scores, as well as ultra-processed foods and longevity.

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