Project Grant R01AG081520
Award Date
8/1/24
Completion Date
7/31/29
Dollars Obligated
$685K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60611, USA
Similar Awards
This $258,498 Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will support a study led by the University of California, Los Angeles (UCLA) to investigate the biological pathways linking sleep health, Alzheimer's disease, and cognitive decline.
The multi-year project has three main aims: 1) using a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia in a...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $2,087,640 in funding to The Regents of the University of California, San Francisco (UCSF) to conduct a study on the effects of sleep disturbances on cognitive decline and Alzheimer's disease risk across the lifespan.
The study aims to leverage data from six longitudinal cohorts, including diverse populations, to examine the relationships between objective and subjective...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,342,815 will fund a study entitled "Delirium Dynamics: Understanding Causes and Effects" at Northwestern University. The research project aims to apply novel continuous monitoring techniques to investigate how specific disturbances in sleep-wake activity and circadian rhythms impact the acute fluctuations and long-term cognitive outcomes of delirium in...
This federal Project Grant award for $191,700, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports Dr. Minjee Kim's research on sleep health and cognitive function among middle-aged adults. Specifically, the award will fund Dr. Kim's investigation of the associations between sleep disturbance, cognitive function, self-care capacity, and health status (Aim 1), as well as the development of sleep disturbance prediction models from electronic health record data...
The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158.00 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The goal is to create a testable prototype device that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. Successful completion of this...
This federal Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) provides $134,000 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct a pilot study on a digital cognitive behavioral therapy for insomnia (DCBT-I) intervention for older adults undergoing elective orthopedic surgery.
The key objectives are to establish the feasibility of the DCBT-I protocol in this patient population and examine its effects...
This K99/R00 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Scripps Research Institute provides $132,300 to investigate the role of protein tyrosine phosphatase 1B (PTP1B) in Alzheimer's disease pathophysiology and associated sleep disturbances.
The key objectives are to 1) determine if inhibition of PTP1B by the small molecule CX08005 can improve sleep/wake patterns, neuropathology, and cognitive performance in Alzheimer's disease mouse models,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $442,938 in funding to The Regents of the University of California, San Francisco (UCSF) to conduct research on the relationship between sleep, memory, and age-related cognitive decline.
The key objectives are to:
Characterize changes in sleep patterns, synaptic plasticity, and brain activity that occur with aging and impact memory consolidation
Determine if upregulating the unfolded protein...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to investigate the utility of afternoon phototherapy (light exposure) to reduce sleep-wake fragmentation and improve cognition in older adults with mild cognitive impairment.
The $131,085 award will fund a research training plan and clinical trial conducted by Dr. Lok at Stanford University. Specifically, Dr. Lok will leverage state-of-the-art machine...