Project Grant R01AA033369
- The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $613,750 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate brain glucose metabolism dysfunction in alcohol use disorder. The research examines how alcohol activates the mTORC1 signaling pathway in dopamine D1 receptor-expressing neurons within the nucleus accumbens, leading to suppression of glycolytic enzymes including aldolase A and...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
- The National Institute on Alcohol Abuse and Alcoholism awarded Icahn School of Medicine at Mount Sinai $3.112 million on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate histone acetylation and synaptic mechanisms underlying resilience to compulsive-like alcohol drinking. The recipient will conduct research on the role of SIRT7, a histone deacetylase, in D1-type medium spiny neurons within the dorsomedial striatum, examining how epigenetic changes and synaptic...
- The National Institute on Alcohol Abuse and Alcoholism awarded Wake Forest University Health Sciences $1,289,726 on September 12, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex collected before alcohol use. The work identifies epigenetic signatures predisposing individuals to risky alcohol use and alcohol use disorder by analyzing differentially methylated regions associated...
- The National Institute on Alcohol Abuse and Alcoholism awarded Children's Research Institute $648,180 on June 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms and potential pharmacotherapy of neurocognitive deficits in fetal alcohol spectrum disorders. The research examines the long-term neurobehavioral impact of prenatal alcohol exposure, with focus on apolipoprotein E (APOE) signaling in the motor cortex as a therapeutic target. The project builds on...
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $488,077 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate molecular and functional adaptations in the nucleus reuniens, a midline thalamic region implicated in alcohol-related cognitive deficits. The research addresses how chronic alcohol exposure produces cognitive dysfunction that impairs treatment outcomes and increases relapse risk. The project will...
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Health Science Center at San Antonio $664,792 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate post-transcriptional mechanisms and cellular senescence in age-related alcoholic liver disease. The research targets dysregulated nutrient sensing as a hallmark of aging that drives hepatic steatosis progression toward cirrhosis and hepatocellular carcinoma. The recipient will...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Tufts College $686,774 on July 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct behavioral neurobiology research on stress, alcohol responsivity, and alcohol drinking patterns. The research uses rodent models to investigate how stress exposure alters sensitivity to alcohol's aversive effects and the neural circuits involved. The study employs classical and operant conditioning paradigms combined with...
- The National Institute on Alcohol Abuse and Alcoholism awarded Loyola University of Chicago Health Sciences Campus $470,066 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct basic research on the molecular mechanisms by which ABL kinase 2 (ABL2) contributes to alcohol-associated liver disease pathogenesis. The research will investigate three specific areas: the molecular mechanisms by which ABL2 promotes alcohol-induced steatosis; the role of ABL kinases in...
The National Institute on Alcohol Abuse and Alcoholism awarded The Washington University $555,331 on August 13, 2026, under the Alcohol Research Programs (CFDA 93.273) to examine the metabolic-epigenetic regulation of alcohol intake and associated molecular mechanisms. The funded research explores how alcohol-derived acetate generated during alcohol metabolism affects brain histone acetylation and subsequently influences alcohol intake behavior. The project builds on preliminary findings demonstrating that acetyl-CoA synthetase 2 (ACSS2), a nuclear metabolic enzyme, mediates the conversion of alcohol-derived acetate into acetyl-CoA and deposits it on histones in the brain. Prior work showed this pathway is required for ethanol-induced associative learning underlying craving and relapse, and that mice not expressing ACSS2 consume significantly less alcohol in voluntary intake models. The award funds cutting-edge genomic, proteomic, and behavioral approaches to explore the mechanistic aspects of behavioral and transcriptional regulation by alcohol-derived acetate. The work is performed at The Washington University's Office of Sponsored Research Services in St. Louis, Missouri, with a performance period extending to May 31, 2031. The Alcohol Research Programs support research to develop fundamental knowledge applicable to improved treatment methods and prevention strategies for alcoholism and alcohol-related problems across biomedical, genetic, psychological, environmental, and health services research disciplines.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $555.3k | 8/17/26 |