Project Grant R01AA033136
- The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $613,750 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate brain glucose metabolism dysfunction in alcohol use disorder. The research examines how alcohol activates the mTORC1 signaling pathway in dopamine D1 receptor-expressing neurons within the nucleus accumbens, leading to suppression of glycolytic enzymes including aldolase A and...
- The National Institute on Alcohol Abuse and Alcoholism awarded Public Health Institute $1,291,065 under the Alcohol Research Programs (CFDA 93.273) on September 20, 2025. The project conducts analyses of alcohol-related mortality in the United States with emphasis on spirits consumption, examining mortality rate relationships with beverage-specific per capita consumption and policy interventions. The work addresses mortality trends that have increased dramatically since 1999 and particularly...
- The National Institute on Alcohol Abuse and Alcoholism awarded $4,718,683 to the Regents of the University of California, San Francisco on September 25, 2025, under the Alcohol Research Programs (CFDA 93.273) to establish the Center for Alcohol/HIV Innovations and Biomarker Research (CALIBER), a comprehensive research, training, and dissemination program addressing the intersection of unhealthy alcohol use and HIV transmission and comorbidity. CALIBER will develop and pilot test a motivational...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Southern California $1,484,578 on September 10, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a randomized controlled study examining personalized phenotypic and genotypic feedback on early drinking trajectories among college students of Northeast Asian descent. The study assesses 450 college students and compares phenotypic risk communication regarding alcohol metabolism and cancer risk with...
- The National Institute on Alcohol Abuse and Alcoholism awarded The General Hospital Corporation (Massachusetts General Hospital) $226,125 on May 11, 2026, under the Alcohol Research Programs Project Grant (CFDA 93.273, R34AA032300). The recipient will conduct a pilot randomized controlled trial (REINFORCE Trial) integrating contingency management with phosphatidylethanol (PETH) biomarker testing to promote alcohol abstinence in patients with alcohol-associated liver disease (ALD) seen in...
- The National Institute on Alcohol Abuse and Alcoholism awarded Cedars-Sinai Medical Center $1.235 million under the Alcohol Research Programs (CFDA 93.273) on September 10, 2025, to investigate the role of prohibitin 1 (PHB1) in ethanol's sensitizing effect on colorectal liver metastasis. Research will examine how excessive alcohol intake depletes hepatocyte nuclear and cytosolic PHB1, increasing matrix metalloproteinase-7 (MMP-7) expression and rendering the liver susceptible to colorectal...
- The National Institute on Alcohol Abuse and Alcoholism, a component of the Department of Health and Human Services National Institutes of Health, awarded Kaiser Foundation Hospitals $2,591,645 on August 5, 2026, under the Alcohol Research Programs (CFDA 93.273) to develop and validate risk-prediction models for alcohol-associated liver disease and metabolic dysfunction-associated steatotic liver disease with unhealthy alcohol intake. The recipient will conduct a multi-method study based at...
- The National Institute on Alcohol Abuse and Alcoholism awarded Kaiser Foundation Hospitals $759,219 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct early identification research on alcohol-associated liver disease in primary care settings. Kaiser Foundation Hospitals, through its Kaiser Foundation Research Institute division, will recruit 1,300 patients to determine the prevalence of current liver disease using transient elastography across all AUDIT-C...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Michigan $2,105,899 on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a fully-powered randomized controlled trial testing the efficacy of a social-media-based intervention for high-intensity drinking among emerging adults. The intervention delivers eight weeks of motivational interviewing-based content through private social media 1:1 messaging with health coaches,...
- The National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health within the Department of Health and Human Services, awarded $682,736 to Beth Israel Deaconess Medical Center, Inc. on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate myeloid-derived suppressor cells (MDSCs) in alcohol-associated steatohepatitis. The award funds research characterizing MDSC phenotypes and immunoregulatory capacity in alcohol-associated hepatitis...
The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $696,490 on July 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct the Redefining Optimal Phosphatidylethanol (PETH) Cutoffs for Alcohol Screening (ROCS) study. The project will recruit 900 persons who drink alcohol from a large urban health system's electronic health records to establish evidence-based PETH cutoff values for detecting unhealthy alcohol use in primary care settings. Current PETH cutoffs lack validation against objective alcohol consumption data and do not account for sex and body mass index, which affect alcohol metabolism. The study will measure alcohol use over 28 days using wrist-worn biomonitoring technology as a gold standard to determine appropriate PETH cutoffs stratified by individual characteristics. The research addresses the gap between recommended annual alcohol screening and low clinical utilization, hypothesizing that improved biomarker-based detection could better identify unhealthy drinking across the spectrum from moderate drinking excess to severe alcohol use disorder and facilitate targeted interventions. Work is performed in San Francisco, California. The period of performance extends from July 20, 2026, through March 31, 2031. The funding mechanism is a project grant, a standard vehicle under which NIAAA supports research to develop improved treatment methods and prevention strategies for alcohol-related problems.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/24/26 | ||
| Not listed | $696.5k | 7/22/26 |