Project Grant R01AA032538
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $167,500 in Project Grant funding to the University of Massachusetts Medical School on September 17, 2025, through the Alcohol Research Programs (CFDA 93.273) for a research study investigating sex differences in excessive alcohol use patterns across young adulthood and middle age. The research will utilize longitudinal data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine how...
- The National Institute on Alcohol Abuse and Alcoholism, under the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Minnesota $400,585 on July 16, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the spinal mechanisms of alcohol-induced tactile hypersensitivity. The research addresses the relationship between chronic alcohol consumption and heightened pain sensitivity in individuals with alcohol use disorder. The...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of North Carolina at Chapel Hill $168,915 on August 17, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the functional role of glutamatergic neurons in the cortical amygdala in regulating alcohol drinking and anxiety-related behaviors in mice exposed to chronic intermittent ethanol vapor, a model of alcohol dependence. The project runs through July 31, 2031, with performance at Chapel Hill, North...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Minnesota $157,040 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) project grant F32AA032727. The funded research investigates neural mechanisms driving compulsive alcohol drinking despite negative consequences, termed aversion-resistant alcohol drinking (ARD). Using optogenetics and simultaneous in-vivo electrophysiology in male and female Long-Evans rats, the project examines how...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Washington University $555,331 on August 13, 2026, under the Alcohol Research Programs (CFDA 93.273) to examine the metabolic-epigenetic regulation of alcohol intake and associated molecular mechanisms. The funded research explores how alcohol-derived acetate generated during alcohol metabolism affects brain histone acetylation and subsequently influences alcohol intake behavior. The project builds on preliminary findings...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $713,580 on August 6, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct imaging research on sex differences in the cortical reward system of people with alcohol use disorder. The research examines dopamine neurotransmission in the mesocortical pathway—which regulates executive functions, reward sensitivity, stress response, and cognitive function—comparing men and women with alcohol use disorder....
- The National Institute on Alcohol Abuse and Alcoholism awarded Drexel University $450,372 on July 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate ethanol-induced dysregulation of the astrocyte glucocorticoid system and its role in comorbid alcohol use disorder and depression, particularly in women. The research examines how chronic ethanol exposure perturbs the astrocyte glucocorticoid receptor system, which contributes to stress responsivity, aversion-related...
- Federal Grant Award Summary Northwestern University received a $2.1 million Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 23, 2025, through August 31, 2029. The project delivers fundamental neuroscience research investigating the neuropeptidergic regulation of valence processing and its contribution to sex differences in alcohol use disorder (AUD) development. The research focuses...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Minnesota $616,849 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate sex differences in cholinergic signaling during alcohol withdrawal. The research examines how acetylcholine signaling in the mesopontine tegmentum and its connections to the ventral tegmental area contribute to alcohol withdrawal symptoms, with particular focus on distinct mechanisms between male and female mice. Preliminary data show that male mice experience withdrawal-induced anxiety and compulsive-like behaviors that persist for at least 21 days and can be attenuated by nicotinic acetylcholine receptor antagonists, while female mice exhibit different patterns of cholinergic activity following chronic alcohol exposure and withdrawal. The project aims to establish a mechanistic foundation for developing more effective alcohol use disorder therapies, particularly for women, by reverse-translating sex-specific findings from preclinical models. The award funds performance in Minnesota through July 31, 2031. The assistance type is a Project Grant, which supports research projects recommended for approval by the National Advisory Council on Alcohol Abuse and Alcoholism. The grant program funds fundamental research applicable to improved treatment methods and prevention strategies for alcoholism and alcohol-related problems across biomedical, genetic, psychological, and environmental domains.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $616.8k | 8/3/26 |