Project Grant R01AA031477
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- This federal Project Grant award for $156,486.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The goal of the project is to investigate the role of beta2 nicotinic acetylcholine receptors in the insula-BNST pathway and their impact on ethanol consumption and abstinence-induced negative affect. The awardee, Wake Forest University Health Sciences, will conduct research to better understand the molecular mechanisms...
- This Project Grant award, totaling $560,108.00 and spanning September 15, 2025 to August 31, 2030, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The purpose of the project is to investigate the neurocognitive mechanisms that promote resilience to alcohol use disorder (AUD) in individuals with a family history of AUD. Specifically, the research will examine how attentional abilities may...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This federal Project Grant award of $154,019 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) to Washington State University supports research on the relationship between stress, cognition, and alcohol biomarkers in real-world settings. The grant aims to characterize the links between laboratory and real-world stress biomarker measures, examine the associations between stress and alcohol biomarkers in real-world settings, and determine if...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs) provides $647,330 to Wake Forest University Health Sciences to conduct research on the role of epigenetics in predisposing the brain to risky alcohol use. The researchers will perform a longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex to identify biomarkers associated with future alcohol drinking levels. The goal...
- This federal Project Grant award of $2,150,570 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Brown University. The funding supports research to investigate the circuit and molecular mechanisms through which alcohol influences natural reward systems in the brain. Specifically, the project aims to use the reduced numerical complexity of the Drosophila (fruit fly) reward/dopaminergic system as a model to study...
- This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research on the role of somatostatin in the central amygdala in relation to heavy alcohol drinking. The research team at Boston University Medical Campus will use an animal model of heavy alcohol drinking, combined with pharmacological, molecular, and electrophysiological approaches, to test the hypothesis that activation of...
- This Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), which falls under the federal Alcohol Research Programs (CFDA 93.273). The $692,723 award will support a double-blind, placebo-controlled clinical trial to test whether the drug suvorexant can be used as a novel therapeutic for alcohol use disorder (AUD) and stress-related drinking. The 5-year project, running from September 2025 through August 2030, will be conducted by researchers at The...
This federal Project Grant award of $2,552,568.00, awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) program, supports research to investigate the relationship between stress-induced neuroadaptations in the insula-BNST pathway and subsequent alcohol use disorder (AUD)-related behavior. The project, conducted by Wake Forest University Health Sciences, aims to elucidate how stress activation of AUD-associated neurocircuitry could reveal unique patterns that predict the development of AUD. The research will test the hypothesis that stress-induced changes in the insula-BNST circuit are associated with future AUD-related behavior, with the goal of informing preventative strategies to mitigate AUD risks. The award period runs from Sep 5, 2025 to Aug 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 9/3/25 |