Project Grant R01AA031671
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University, doing business as Indiana University Indianapolis, $381,363 on August 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to support research on inhibitory corticostriatal circuit mechanisms underlying binge alcohol drinking. The award funds investigation of how alcohol alters synaptic function in neural circuits that contribute to alcohol use disorder progression, specifically focusing on...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University (Indiana University Indianapolis) $138,118 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct an integrative multi-omics study identifying cell-type and brain-region specific genetic drivers of alcohol use disorder. The recipient will perform differential expression and chromatin accessibility analyses using single-nucleus RNA-seq and ATAC-seq data from four brain regions...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University (doing business as Indiana University Indianapolis) $760,785 under the Alcohol Research Programs (CFDA 93.273) on August 1, 2026. The award funds a pragmatic stepped-wedge cluster randomized trial testing infection mitigation measures (IMM) in patients with advanced alcohol-associated liver disease (AALD). The trial will enroll approximately 1,000 patients with AALD at four leading U.S. centers and...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University (Indiana University Indianapolis) $492,012 on September 12, 2025, as a Project Grant under the Alcohol Research Programs (CFDA 93.273) to investigate the mechanism of neutrophilic NCF1 in alcohol-associated liver disease pathogenesis. The research examines how neutrophils drive disease severity and mediate liver injury in alcohol-associated liver disease (ALD), with specific focus on the NCF1 gene's...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Trustees of Indiana University (Indiana University Indianapolis) $163,824 on May 4, 2026, under the Alcohol Research Programs (CFDA 93.273) as a Project Grant (K08 award K08AA032351). The award funds research and training on intergenerational trauma and youth alcohol use, specifically examining how maternal post-traumatic stress disorder affects youth neurobiology and alcohol consumption. The principal investigator will acquire...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
- The National Institute on Alcohol Abuse and Alcoholism awarded Palo Alto Veterans Institute For Research $1,091,712 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a randomized, double-blind, sham-controlled trial assessing deep transcranial magnetic stimulation (DTMS) as a treatment for alcohol use disorder. The research enrolls 100 adults with alcohol use disorder into a mechanistic trial evaluating whether active DTMS targeting the medial prefrontal...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $488,077 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate molecular and functional adaptations in the nucleus reuniens, a midline thalamic region implicated in alcohol-related cognitive deficits. The research addresses how chronic alcohol exposure produces cognitive dysfunction that impairs treatment outcomes and increases relapse risk. The project will...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $613,750 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate brain glucose metabolism dysfunction in alcohol use disorder. The research examines how alcohol activates the mTORC1 signaling pathway in dopamine D1 receptor-expressing neurons within the nucleus accumbens, leading to suppression of glycolytic enzymes including aldolase A and...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $628,080 under the Alcohol Research Programs (CFDA 93.273) on May 1, 2026. This Project Grant (R01AA032487) funds a five-year investigation into whether a hyperactive nociceptin opioid peptide receptor (NOP) system drives relapse in heavy drinking alcohol use disorder (AUD) subjects, using positron emission tomography imaging with [11C]NOP-1A radiotracer and hydrocortisone challenge protocols. Prior...
The National Institute on Alcohol Abuse and Alcoholism, part of the Department of Health and Human Services National Institutes of Health, awarded $702,720 to Indiana University Indianapolis on August 10, 2026, under the Alcohol Research Programs (CFDA 93.273) project grant R01AA031671. The award funds research investigating posterior default mode network modulation as a treatment target in alcohol use disorder. The research examines how dysfunction in the medial posterior default mode network—comprising the precuneus and posterior cingulate cortex—contributes to craving, relapse, reward-seeking behavior, and impaired decision-making in AUD. The project applies non-invasive neuromodulation techniques including repetitive transcranial magnetic stimulation, specifically intermittent and continuous theta burst stimulation, to modulate posterior default mode network activity and alter interactions between the default mode network, salience network, and cognitive control network. The research aims to establish a causal understanding of network dysfunction and develop novel neural circuit-based interventions for substance use disorders. Performance occurs in Indianapolis, Indiana, through July 31, 2031. The award is a project grant, the standard assistance type under the Alcohol Research Programs, which supports research in biomedical, genetic, psychological, environmental, and prevention factors related to alcoholism and alcohol-related problems.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $702.7k | 8/12/26 |