This Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a postmortem, multi-omic study of brains from 341 total subjects to identify novel lasting transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research will analyze RNA sequencing and whole-genome bisulfite sequencing data across 8 brain...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,373,036 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Yale University. The overarching goal of this 5-year research project (Sep 2024 - Aug 2029) is to enhance the understanding and prediction of heavy drinking episodes during initial recovery from alcohol use disorder (AUD). The project aims to leverage wearable biosensor technology and artificial intelligence to develop real-time predictive...
This federal Project Grant award of $581,869 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the CFDA 93.273 Alcohol Research Programs, will fund a human neuroscience study to investigate the role of glucocorticoid receptor (GR) antagonism in alcohol use disorder (AUD). The study will evaluate the effects of a selective GR antagonist, PT150, on behavioral, neuroendocrinological, and physiological responses to stress and alcohol in 34 participants. The research aims...
This $711,808 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a multi-year research project at Yale University to investigate the neural mechanisms underlying the stress response and its relationship to chronic alcohol consumption. The key objectives of the research are to: 1) develop a connectome-based model to predict stress responses using functional MRI data, 2) characterize dynamic...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under CFDA Program 93.273 - Alcohol Research Programs, will support research on avoidance learning and pain circuit dysfunction in alcohol use disorders (AUD). The $497,581.76 award, effective September 10, 2024, will enable the principal investigator at Yale University to collect functional MRI data from treatment-seeking AUD patients during a probabilistic learning task involving pain and reward....
This federal Project Grant award of $1,135,243 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to investigate changes in neural mechanisms associated with cognitive reappraisal and alcohol cue reactivity during early abstinence from alcohol use disorder (AUD) treatment. The research, conducted by the University of Colorado-Denver and involving sub-awards to Emory University and the University of Denver,...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
This $366,406 Project Grant was awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Yale University. The grant will be used to develop two novel human laboratory models to screen potential medications for Alcohol Use Disorder (AUD). The first model will assess a medication's ability to increase abstinence and reduce heavy drinking, which align with key FDA endpoints for AUD medication approval. The second model will...
This federal Project Grant award of $710,992, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports a longitudinal study to understand the trajectory, mechanisms, and impacts of changes in emotion processing deficits during early alcohol use disorder (AUD) recovery. The University of Florida, the primary awardee, will recruit recently abstinent individuals in residential AUD treatment and a matched community control...
This Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to investigate the neural mechanisms driving adaptive stress coping behaviors and subsequent alcohol use. The $498,121.57 award, effective August 15, 2024 through July 31, 2027, will utilize an animal model to explore how dysfunction in the corticolimbic circuitry, specifically the prelimbic cortex and basolateral...