This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $1,373,036 to Yale University to conduct research aimed at enhancing the understanding and prediction of heavy drinking episodes during initial recovery from alcohol use disorder (AUD). The project will leverage wearable biosensor technology and artificial intelligence to develop real-time predictive models that can forecast periods of heightened...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will provide $701,135 to Yale University to characterize brain and peripheral cortisol dysregulation in individuals with alcohol use disorder (AUD). The project aims to fully describe the availability of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which regulates cortisol levels in the brain, and to...
This Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a postmortem, multi-omic study of brains from 341 total subjects to identify novel lasting transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research will analyze RNA sequencing and whole-genome bisulfite sequencing data across 8 brain...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $194,551 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Medical University of South Carolina. The funding supports research to investigate the effects of adolescent intermittent ethanol exposure on the regulation of a neural pathway involving the prelimbic cortex and ventrolateral periaqueductal gray, and its impact on pain processing and sensitivity. The research aims to elucidate how changes in the...
This $366,406 Project Grant was awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Yale University. The grant will be used to develop two novel human laboratory models to screen potential medications for Alcohol Use Disorder (AUD). The first model will assess a medication's ability to increase abstinence and reduce heavy drinking, which align with key FDA endpoints for AUD medication approval. The second model will...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $165,279 to the University of Washington to conduct research on understanding the neural markers of incentive salience for alcohol cues. The goal is to characterize the brain-behavior mechanisms driving alcohol use behaviors in everyday life, leveraging a combined laboratory-ambulatory study design. The research aims to examine how features...
This federal Project Grant award, totaling $517,248.00, was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The award supports research to explore the mechanisms by which acute and chronic alcohol exposure regulate a norepinephrine-astrocyte-dopamine arousal pathway in the ventral periaqueductal gray (VPAG) region of the brain, and how this pathway contributes to alcohol-related changes in sleep behavior....
This $711,808 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a multi-year research project at Yale University to investigate the neural mechanisms underlying the stress response and its relationship to chronic alcohol consumption. The key objectives of the research are to: 1) develop a connectome-based model to predict stress responses using functional MRI data, 2) characterize dynamic...
This Project Grant award for $545,282 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to investigate neural mechanisms associated with cognitive reappraisal and alcohol cue reactivity in individuals with alcohol use disorder (AUD) during early abstinence. The key objectives are to: 1) determine how neural mechanisms related to reappraisal and alcohol cue-reactivity change across early abstinence...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $159,056 to The Washington University in St. Louis to investigate the role of a novel dynorphinergic central amygdala-nucleus accumbens circuit in driving binge-like alcohol drinking during persistent pain and protracted fentanyl abstinence. The research aims to elucidate the circuit-level mechanisms underlying the co-occurrence of chronic...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $497,581.76 to Yale University to conduct research on avoidance learning and pain circuit dysfunction in alcohol use disorders (AUD). The key objectives are to: 1) Characterize dysfunctions of brain circuits supporting pain reactivity and cognitive control during avoidance learning in AUD patients compared to social drinkers; 2) Evaluate how neural markers, along with clinical, physiological and behavioral metrics, can be used to diagnostically distinguish AUD characteristics and model pathophysiological pathways sustaining habitual alcohol use; and 3) Identify risk factors that predict relapse during a 12-month follow-up. This research aims to improve understanding of the neural, physiological, and psychological processes linking avoidance learning dysfunction to the maintenance and relapse of AUD, with potential clinical implications for enhancing treatment outcomes. The award period is from Sep 10, 2024 to Aug 31, 2027.