Project Grant R35GM159905
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- The federal Project Grant award of $673,600.00 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop an RNA-based sensor that can detect changes in both mRNA and miRNA within living cells and mouse models. The objective is to create a programmable, synthetic biology tool that can identify diseased cells based on their RNA profiles and trigger...
- This federal Project Grant award of $436,001 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to create a novel spatial transcriptomics platform that increases accessibility and efficiency. The key products and services to be delivered include: Developing a spatial transcriptomics platform using a simple filter array format that increases sequencing depth per spatial barcode, enabling more data per...
- The U.S. National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $432,834 Project Grant to the Board of Regents of the University of Nebraska on April 15, 2025. The grant supports the development of an "enzyme-free, label-free quantitative microarray technology" to detect and quantify target nucleic acids, such as microRNA, with high sensitivity down to the attomolar (10^-18 M) range....
- This federal Project Grant award of $427,625 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop capillaric microfluidics for integrated sample preparation in miniaturized mass spectrometry (mini-MS) systems. The research will focus on creating portable, self-powered, and self-regulated sample preparation capabilities to improve the versatility and applicability of mini-MS instruments for...
- This federal Project Grant award of $654,950.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a unified framework for generating oligonucleotide-based receptors (aptamers) to detect a variety of small molecule targets that are difficult to isolate using standard protocols. The research, conducted by The Trustees of Columbia University in the City of New York, will address two...
- The federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development and demonstration of a novel enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. This innovative platform leverages enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Electronic Biosciences, Inc. to develop the first technology capable of high-accuracy sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A) using nanopore sequencing. The project aims to merge innovative bisulfite adduct methodology with Electronic Biosciences' enzyme-free, multipass...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
- This $445,000 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on leveraging long-read transcriptomics to elucidate transcriptome complexity and advance genomic medicine. The central objective is to harness the power of long-read RNA sequencing to provide unprecedented insights into alternative splicing and its impact on gene products, which is...
This federal Project Grant award for $390,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of new tools for high-throughput characterization of extracellular RNA, DNA, and vesicles in bodily fluids. The primary objectives are to: 1) develop methods to reliably control for technical variability, RNA degradation, and complexity in cell-free RNA (cfRNA) analysis, including identifying an intrinsic cfRNA reference gene set and a k-mer-based classification approach; and 2) introduce a new technique to induce epigenetic contrast of cell-free nucleosomes directly in body fluids through polyamine-mediated phase separation, in order to measure and map cell state-specific chromatin features. These advances aim to improve the utility of extracellular biomarkers across a range of disease applications, including oncology, transplantation, obstetrics, and neurological disorders. The award period is from September 1, 2025 to August 31, 2030 and is being provided to the Oregon Health & Science University, a prominent academic medical center and research institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $390.0k | 9/1/25 |