This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to develop novel computational methods for integrating large-scale genomic datasets to better understand the regulatory networks underlying complex human traits and diseases. The $533,801.84 award, effective September 18, 2024 through June 30, 2027, will enable the awardee, The Trustees of the University of Pennsylvania, to: 1) improve causal structure learning methods to better leverage biological knowledge and model poorly captured or difficult-to-intervene genes, and 2) construct a causal network integrating population-scale gene expression and genome-wide association data, benchmarked against CRISPR perturbation experiments in cell lines. The goal is to provide a framework for large-scale estimation of regulatory networks and their role in complex trait biology, potentially revealing avenues for therapeutic intervention.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $35.8k | 12/16/24 | ||
| Not listed | $249.0k | 9/18/24 | ||
| Not listed | $249.0k | 9/18/24 |