Project Grant R01HD119222
- This federal Project Grant award, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of the KIF2C protein in regulating microtubule dynamics during the oocyte-to-embryo transition in zebrafish. The $147,486 award to the University of Pennsylvania aims to elucidate how KIF2C, a microtubule depolymerase, controls...
- The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
- This Project Grant award of $128,214 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research at the University of Michigan to investigate how maternal and paternal centromeric protein levels are balanced during the first cell cycle of mammalian embryogenesis. The overarching objective is to understand the molecular mechanisms that equalize the...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $133,401 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Fred Hutchinson Cancer Center, located in Seattle, WA. The grant, awarded on September 1, 2025, is intended to develop computational models that can identify the sequence of changes a cell undergoes during differentiation and maturation, and compare changes in gene expression...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- This $221,448 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to determine the role of apoptosis (programmed cell death) in oogenesis and oocyte (egg cell) health. The research will be conducted by the University of North Carolina at Chapel Hill using the oogenic germline of the model organism Caenorhabditis elegans. The goal is to...
- This $616,841 project grant was awarded by the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", to Yale University beginning on August 15, 2025 and scheduled for completion on April 30, 2030. The project aims to investigate the molecular mechanisms that regulate genome activation and gene expression during embryonic development in vertebrates, with a focus on understanding how specific...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $595,864 Project Grant to the Magee-Womens Research Institute and Foundation in Pittsburgh, PA, effective August 15, 2025 and scheduled for completion on May 31, 2030. The grant, awarded under the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to elucidate the role of hyaluronan, a key extracellular matrix component, in the development...
- This Project Grant award of $248,994 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which administers the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award will fund research by the Washington University in New York, NY to investigate the mechanisms by which histone mutations affect chromatin structure, gene expression, and neural differentiation during development. The goal is to...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $606,518 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Magee-Womens Research Institute and Foundation. The grant, awarded on June 5, 2025, supports research to develop and test the safety and feasibility of spermatogonial stem cell (SSC) transplantation and testicular tissue grafting techniques for restoring fertility in patients,...
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $497,689 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The goal of this 5-year project is to investigate a novel role for actin in ensuring mitotic fidelity during early mammalian development. The researchers will use advanced imaging techniques to study how actin cables inside the cell nucleus capture chromosomes and initiate chromosome congression before the mitotic spindle fully assembles. They will also examine how a peri-spindle actin network regulates spindle growth and positioning to promote proper cell division patterns in the early mouse embryo. The project aims to elucidate the mechanisms by which these actin networks form, are regulated, and contribute to mitotic fidelity during early development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $497.7k | 8/13/25 |