Project Grant R00DK142197
- This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is focused on developing an anti-MMP-9 monoclonal antibody (MAb) therapeutic for treating diabetic neuropathic pain. The $2,079,796 award, granted on August 11, 2025, aims to optimize and advance a lead anti-MMP-9 inhibitory MAb to Phase I clinical trials for diabetic neuropathic pain. The 5 key objectives are: 1) Hit to lead; 2) Lead...
- This $437,250 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to compare the gene expression of the key cell types that form the blood-nerve barrier (BNB) in the peripheral nervous system and the blood-brain barrier (BBB) in the central nervous system under physiological conditions. The research will also...
- This Project Grant award of $409,887.00 from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the mechanisms leading to small fiber neuropathy and loss of epidermal nerve fibers. The research aims to explore whether epidermal axons comprise a surveillance network that responds to threats on body surfaces, leading to nerve fiber density loss. Key areas...
- This federal Project Grant award of $597,999.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the neuronal populations and central sensitization mechanisms underlying mechanical allodynia (a condition where normally innocuous touch becomes painful after injury) in the dorsal horn. The research aims to identify the excitatory...
- The federal Project Grant award R15NS137207, valued at $389,851, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the Florida Institute of Technology (Florida TECH) to investigate the role of the RPM-1 signaling network in tau protein-related neurodegeneration using a C. elegans tauopathy model. The proposed research...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing a novel drug candidate to treat demyelinating neuropathies. The $352,073 award will support rigorous in vivo testing of the experimental ABCA1 agonist drug, CS6253, in validated mouse models of hereditary peripheral nerve disorders characterized by impaired...
- This federal Project Grant award for $102,876.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research by Temple University-Of The Commonwealth System Of Higher Education to investigate the role of protein palmitoylation in axon degeneration, a key mechanism underlying diverse neurological conditions. The research aims to better...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research by Function Therapeutics Inc. to investigate the use of a new class of small molecule compounds called Parmodulins for the treatment of neuropathic pain. The $499,863 award, granted on September 11, 2025, will fund research to synthesize and test various Parmodulins for their ability to modulate the...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate a novel pharmacological approach to mitigate neurovascular complications associated with type 2 diabetes in stroke patients. The $459,111 award to the University of Tennessee Health Science Center will fund research exploring the beneficial effects and mechanisms of...
- This $4,039,366 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), will support a research project titled "A Fully Humanized Functional Genomic Screen to Identify and Validate Pain Therapeutic Targets" under the NIH's Drug Use and Addiction Research Programs (CFDA 93.279). The project will leverage innovative CRISPR-based screening and human dorsal root ganglion (DRG) transcriptomic data to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $747,000.00 to the University of Central Florida to conduct research on the role of tau phosphorylation in diabetic peripheral neuropathy. The key objectives are to: 1) identify increases in tau phosphorylation and dysregulation of the insulin signaling pathway in the STZ model of type 1 diabetes; 2) confirm the role of GSK3B in tau phosphorylation using a GSK3B inhibitor and genetically engineered mice; and 3) develop new in vivo and in vitro models to examine the effects of GSK3B activation independent of insulin dysregulation. The research aims to provide a breakthrough in understanding diabetic neuropathy that will impact the development of new therapeutics. The award period is from Sep 1, 2025 to Aug 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/26/25 | ||
| Not listed | $747.0k | 8/22/25 |