Project Grant R00DE031762
- This federal Project Grant award, totaling $643,574, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award was granted to Texas A&M University System Health Science Center to conduct research on the therapeutic mechanisms of induced pluripotent stem cell-derived mesenchymal stem cell (iPSC-MSC) extracellular vesicles for treating dry mouth caused by Sjögren's syndrome or radiation...
- This Project Grant award of $409,960 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support the development of a human salivary gland-on-a-chip model at Texas A&M University System Health Science Center. The goal is to establish normal and radiation-damaged salivary gland models that incorporate epithelial cells, endothelial cells, and macrophages to better understand and develop treatments for...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is supporting research to identify mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth after radiation therapy. The $714,711 award to the Icahn School of Medicine at Mount Sinai will fund the development of a scalable gene targeting system to test over 2,600 genetic...
- This $429,000 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund research to evaluate the therapeutic potential of targeting phosphodiesterase-4 (PDE4) enzymes as a novel approach to alleviate symptoms and address the underlying causes of salivary gland dysfunction and xerostomia (dry mouth) associated with Sjögren's syndrome. The research will be conducted by the University of...
- This Project Grant award of $174,418.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to determine the function of TRP-positive trigeminal sensory neurons innervating the submandibular salivary glands. The objective is to understand how this direct sensory innervation of the submandibular glands by trigeminal neurons contributes to the regulation of saliva production and...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $248,750 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) located in Cambridge, Massachusetts. The grant will support research to determine the impact of cellular senescence on Sjögren's Syndrome-associated salivary gland dysfunction and salivary gland stem cell activity, with the goal of developing effective...
- This Project Grant award, titled "Defining the Role of Tissue-Resident Macrophages During Salivary Gland Morphogenesis", was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The $100,676 award to the Icahn School of Medicine at Mount Sinai will fund research to determine the functional contribution of tissue-resident macrophages in regulating salivary gland development, including...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to elucidate how immune cells, specifically tissue-resident macrophages, regulate the coordinated processes of salivary gland epithelial cell development and differentiation. The $628,965 award to the Icahn School of Medicine at Mount Sinai will leverage expertise in salivary gland biology, progenitor cell dynamics, and...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of California, San Diego (UCSD) for the project "Engineering Mucin Analogues to Benefit the Mouth Environment." The project aims to create advanced mucin substitutes that closely emulate the physiological functions of natural salivary mucins, in order to develop enhanced artificial saliva...
- This federal Project Grant award of $644,970.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a research project to investigate immune-epithelial interactions and their impact on restoring salivary gland function after radiation therapy. The long-term goal is to develop mechanisms for restoring salivary gland function in head and neck cancer patients who suffer from chronic xerostomia (dry...
This $249,000 federal Project Grant, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to identify cell fate determination processes specific to salivary cell populations in order to advance regenerative therapies. The principal investigator at Rutgers, The State University of New Jersey will conduct studies to understand the normal developmental processes and transcriptional and lineage plasticity of different salivary gland cell types, including the parotid gland, which is most susceptible to dry mouth conditions. The goal is to develop a mechanistic framework for identifying therapeutic targets to improve regenerative treatments for salivary gland diseases and disorders. The award period is from September 1, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/26/25 |