Project Grant R01DA063090
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $608,652 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Scripps Research Institute. The purpose of this 5-year award, with a start date of September 1, 2025, is to conduct data mining and functional validation of the Systematic Characterization of Retroviral Conditions for Health (SCORCH) datasets. The research aims to elucidate the key pathogenic...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $558,668 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Massachusetts Institute of Technology (MIT) for the project "Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV". The project aims to uncover the genetic and molecular mechanisms driving the interactions between HIV, neuropsychiatric, and...
- The National Institute on Drug Abuse (NIDA) awarded a $569,743 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Yale University on July 15, 2025. The grant, titled "Y-SCORCH 2.0: Further Data Mining and Functional Characterization for Single Cell Opioid Responses in the Context of HIV (SCORCH) Program," aims to leverage advanced tools to analyze transcriptomic and epigenetic data from the SCORCH consortium and novel spatial transcriptomic data to...
- This $585,975 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is funding research to discover and functionally characterize long non-coding RNAs (lncRNAs) in the context of opioid use disorder (OUD) and HIV at single-cell resolution. The University of Massachusetts Medical School (UMMS) is the primary awardee and will leverage large single-cell RNA sequencing datasets from NIH programs like SCORCH and...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- The federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $439,180 to The Johns Hopkins University to investigate the role of dopaminergic neuron-glial interactions in the striatum in the context of HIV infection and substance use disorders. The research aims to deconvolute the complex interplay between HIV, methamphetamine use, and alterations in dopamine signaling pathways, which can contribute...
- This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
- This Project Grant award of $1,573,958 from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on identifying individuals who are viremic and/or have substance use disorder (SUD) to engage them for early intervention. The project will implement routine SUD screening using the NIDA Quick Screen and a social network intervention to find individuals who are viremic, have SUD, or both, and link them to harm reduction and HIV...
- This federal Project Grant award of $248,717 from the National Institute on Drug Abuse (NIDA), under CFDA program 93.279 - Drug Use and Addiction Research Programs, supports research to investigate the neural circuits and mechanisms underlying orbitofrontal cortex signaling during learning. The project aims to test the hypothesis that the formation of integrated representations in the orbitofrontal cortex depends on activity in chemosensory, motor, and limbic areas, and that orbitofrontal cortex...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,080,885 to the University of Southern California (USC) from September 2024 to September 2027. The funding supports the development of novel neural network models that can capture the nonlinear dynamics of large-scale brain networks and their relationship to behavior. The models will have flexible inference capabilities, enabling real-time,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a comprehensive effort to analyze hundreds of multi-omic datasets related to the impact of substance use disorders (SUD) and HIV on the brain's reward circuitry and neuroinflammation. The $556,432 award, commencing on September 1, 2025, will enable researchers at the University of Maryland, Baltimore to: Assemble a harmonized resource of multi-omic datasets, combining data from the SCORCH consortium with additional datasets profiling transcriptomes, epigenomes, single cells, spatial positions, sorted neurons/glia, and bulk brain tissues from humans, non-human primates, and rodents. Conduct joint analyses across this data compendium using newly developed techniques in joint decomposition and transfer learning to identify molecular signatures associated with SUD and HIV. Create a web-based data visualization and analysis portal to democratize access to these findings for the broader research community. This comprehensive, multi-year effort aims to overcome barriers impeding the full utilization of existing multi-omic data on SUD and HIV, leading to the discovery of new biological mechanisms and therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $556.4k | 8/25/25 |