Project Grant R00AG088305
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $210,513 on July 20, 2026, under the Aging Research program (CFDA 93.866) to characterize molecular products of TDP-43 dysfunction as neuroinflammatory targets in amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). The research investigates the interplay between TDP-43 dysfunction and antigen generation that drives maladaptive neuroinflammation in ALS-FTD. The work comprises two aims:...
- The National Institute on Aging awarded The Washington University $162,000 on March 1, 2026, under the Aging Research program (CFDA 93.866) to identify and characterize new therapy targets in TDP-43 proteinopathies. The award supports research into the mechanisms by which TDP-43 mislocalization results in neuronal death and aims to discover previously unidentified therapy targets that mediate this disease process. TDP-43 pathology is observed across multiple neurodegenerative diseases...
- The National Institute on Aging awarded New York University $422,297 under the Aging Research program (CFDA 93.866) on February 15, 2026, to investigate mechanisms of dysregulated protein synthesis in human neurons carrying frontotemporal dementia–associated tau mutations. The project uses human induced pluripotent stem cell–derived neurons bearing FTD-associated tau mutations to model how pathogenic tau disrupts protein synthesis. In the first aim, researchers will determine the impact of...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $3.21 million Project Grant (CFDA 93.866, Aging Research program) effective August 11, 2025, through July 31, 2029, to conduct research characterizing antigen-specific immune responses in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research will employ an unbiased, multidisciplinary approach to identify self- and non-self peptides and antigens...
- The National Institute on Aging awarded the University of Pennsylvania $6.72 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to develop short RNA therapeutics targeting TDP-43 proteinopathy across amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, and chronic traumatic encephalopathy. The recipient will identify and characterize short oligonucleotides that engage the TDP-43 protein,...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging awarded the University of Alabama at Birmingham $486,779 on September 1, 2026, under the Aging Research program (CFDA 93.866) for research into targeted progranulin therapy as a treatment for TDP-43 proteinopathy, a primary pathology of amyotrophic lateral sclerosis, frontotemporal dementia, and a common co-pathology of Alzheimer's disease. The research investigates whether boosting progranulin levels can provide neuroprotection in TDP-43 proteinopathy by...
- The National Institute on Aging awarded the University of Miami $3.73 million on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and internally validate predictive markers and a composite risk score for phenoconversion to clinically manifest amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) in C9ORF72 repeat expansion carriers. The award funds evaluation of leading clinical markers and biomarkers—including presence of prodromal syndrome, thalamic...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $461,900 Project Grant to Pennsylvania State University on May 1, 2025. The grant, titled "Mechanisms Underlying TDP-43 Dependent Structural Deficits in ALS Muscles", will fund research to study the role of the TDP-43 protein in muscle degeneration associated with Amyotrophic Lateral Sclerosis (ALS). The research aims to uncover the mechanisms by which TDP-43 impacts muscle...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Thomas Jefferson University $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to characterize neurodegenerative hallmarks in induced neural stem cells (iNSCs) derived from patient fibroblasts to study dsRNA-mediated inflammation in C9ORF72-associated ALS and frontotemporal dementia. The research employs a novel disease model using age-preserved iNSCs directly...
The National Institute on Aging awarded the University of South Carolina $249,000 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the effects of frontotemporal dementia and amyotrophic lateral sclerosis mutations in RNA-binding proteins on mRNA transport and local translation. The research uses induced pluripotent stem cell-derived neurons with CRISPR-edited FTD/ALS mutations in RNA-binding proteins (TDP-43, FUS, HNRNPA1, HNRNPA2, MATR3, and TIA1) to determine the mRNA and protein components of axonal transport granules, whether mRNAs co-localize within those granules, the role of membrane-bound organelles in local translation, and the role of partial translation in targeting transcripts to sites of local translation. The project applies proximity labeling, spatial transcriptomics, and ribosome profiling to test whether mRNA packaging and partially translated targeting sequences determine ultimate local translation sites and whether these signals are disrupted in FTD/ALS. The award covers the period August 15, 2026, through July 31, 2029, with place of performance in Columbia, South Carolina. This is a Project Grant assistance type supporting biomedical research directed toward understanding aging processes and diseases, particularly Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/13/26 |