Project Grant P30GM165286
- The National Institute of Nursing Research, part of the Department of Health and Human Services National Institutes of Health, awarded $789,558 to The Nemours Foundation on September 1, 2026, under the Nursing Research program (CFDA 93.361). The award funds development and evaluation of the Sickle Cell Disease Shared Decision-Making Toolkit for Adolescents and Young Adults (SDMT-AYA), which addresses barriers to uptake and adherence to disease-modifying therapies among adolescents and young...
- The National Institute of General Medical Sciences awarded the University of Delaware $1.2 million on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support Phase III of the Center of Biomedical Research Excellence in Cardiovascular Health. The Center continues multidisciplinary research aimed at understanding mechanisms underlying poor cardiovascular health and developing effective interventions. Prior phases successfully established independent...
- The National Heart, Lung, and Blood Institute awarded The Children's Hospital of Philadelphia $2,712,905 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop safe, effective, and scalable curative therapies for hemoglobinopathies including sickle cell disease, alpha-thalassemia, beta-thalassemia, and Fanconi anemia by targeting hematopoietic stem cells in vivo using antibody-directed, lipid nanoparticle delivery systems. The research strategy...
- The National Heart, Lung, and Blood Institute awarded Duke University $238,516 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct admixture mapping of genetic modifiers in sickle cell disease. The research leverages the National Heart, Lung, and Blood Institute's TOPMed program, which includes multiple cross-sectional adult sickle cell disease cohorts totaling more than 4,000 participants with whole genome sequencing data and extensive clinical...
- The National Heart, Lung, and Blood Institute awarded $1.834 million to St. Jude Children's Research Hospital Inc. on July 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to test senescence-targeting therapies for improving hematopoietic stem cell function and mobilization in sickle cell disease. The research addresses pathologic bone marrow stress in sickle cell disease patients, which damages and depletes hematopoietic stem and progenitor cells and selects for...
- The National Institute of General Medical Sciences, under the Department of Health and Human Services National Institutes of Health, awarded the University of Delaware $392,495 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of extracellular vesicle biogenesis and uptake. The research examines how cells release distinct extracellular vesicle subpopulations and how those vesicles mediate intercellular transport of bioactive...
- The National Institute of General Medical Sciences awarded Arkansas Children's Research Institute $1,167,290 on August 1, 2026, to establish and operate the Center for Childhood Obesity Prevention at the Arkansas Children's Research Institute under the Biomedical Research and Research Training program (CFDA 93.859). The center addresses pediatric obesity and cardiometabolic disorders in Arkansas and nationally by integrating biomedical discovery, clinical translation, and community engagement....
- The National Institutes of Health Office of the Director awarded The Nemours Foundation $1,074,636 on September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) for research into precision neurostimulation to restore cognitive function across multiple neurological disorders. The funded research combines in-vivo and in-silico approaches to identify and correct disrupted hippocampal activity patterns shared across disease groups. The study uses six animal models of three common...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Children's Hospital of Philadelphia $699,999 on August 15, 2026, for basic research on chromatin remodelers in erythropoiesis and hemoglobin regulation under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funded work dissects molecular mechanisms by which BAF (Brahma-Associated Factor) chromatin remodeling complex subtypes and subunits achieve gene-specific regulation...
- The National Heart, Lung, and Blood Institute awarded Emory University $1,288,327 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on red blood cell survival in recipients with sickle cell disease. The research evaluates the impact of donor and recipient factors on transfused red blood cell (RBC) survival in sickle cell disease patients and examines mechanisms contributing to RBC clearance. The study proposes an experimental,...
The National Institute of General Medical Sciences awarded The Nemours Foundation $1.14 million on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support the Delaware Comprehensive Sickle Cell Research Center (DE SCD COBRE) in Phase 3 funding. The award funds continued operation of a biomedical research center focused on sickle cell disease care and research development. The center recruits and develops sickle cell researchers across multiple disciplines using a matrix mentoring model, implements pilot projects in translational, clinical, and implementation science research, and operates a clinical research and data informatics core to support investigators. During Phase 3, the center will integrate with Delaware's Institutional Development Award programs, including the Delaware INBRE and the Delaware ACCEL Clinical and Translational Research program, and coordinate with research infrastructure at Nemours Children's Hospital to support sustainability beyond the current funding phase. The recipient is Nemours Biomedical Research – Delaware Division, operating as Nemours Children's Hospital, Delaware, a tax-exempt nonprofit research organization located in Wilmington, Delaware. Performance runs through May 31, 2031. Prior COBRE Phase 1 and Phase 2 funding to Delaware exceeded $69 million in total, including institutional and philanthropic contributions that strengthened research in cancer and blood disorders at Nemours Children's Hospital.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 8/11/26 |