Project Grant R21HL188907
- The National Heart Lung and Blood Institute awarded Duke University $313,416 on August 15, 2026, to validate a functional assessment tool for sickle cell disease and pilot an exercise and nutrition intervention. The award supports work under the Cardiovascular Diseases Research program (CFDA 93.837). The project will evaluate the validity and reliability of the Sickle Cell Disease Functional Assessment (SCD-FA) in a prospective cohort of adults with SCD aged 18 years and older, with the...
- The National Heart, Lung, and Blood Institute awarded Emory University $797,648 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate red blood cell-bound cell-free DNA as a predictor of acute anemia in sickle cell disease. The research examines whether elevated levels of cell-free DNA released during vaso-occlusive complications in sickle cell disease bind to toll-like receptor 9 (TLR9) on red blood cells, thereby modulating red blood cell clearance...
- The National Heart, Lung, and Blood Institute awarded the University of North Carolina at Chapel Hill $171,488 on September 30, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a nationwide examination of access to comprehensive care in sickle cell disease. The research uses national Medicaid insurance claims data to address two analytic aims. The first aim identifies three groups of people with sickle cell disease—those who do not receive care from a...
- The National Heart, Lung, and Blood Institute awarded Emory University $1,288,327 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on red blood cell survival in recipients with sickle cell disease. The research evaluates the impact of donor and recipient factors on transfused red blood cell (RBC) survival in sickle cell disease patients and examines mechanisms contributing to RBC clearance. The study proposes an experimental,...
- The National Heart, Lung, and Blood Institute awarded the University of Tennessee Health Science Center $253,395 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify genetic modifiers of acute kidney injury in sickle cell disease. The award funds research evaluating candidate genetic variants—apolipoprotein L1 (APOL1), hemeoxygenase-1 (HMOX1), BCL11A, and alpha thalassemia—for their association with acute kidney injury (AKI) in a well-genotyped and...
- The National Heart Lung and Blood Institute awarded $1.449 million to the University of North Carolina at Chapel Hill on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837, R01HL177199) to conduct a multi-site prospective study examining the prevalence, clinical impact, and treatment response of sleep-associated hypoxemia in adults with sickle cell anemia. The study enrolls adult patients with homozygous sickle cell anemia (SCA) at four institutions—University of...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $232,836 on December 1, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop biomarkers of ischemic risk in adults with sickle cell disease using non-invasive quantitative neuroimaging methods. The research uses arterial spin labeling MRI and other quantitative imaging techniques to test hypotheses regarding cerebral oxygen utilization in patients with sickle cell disease...
- The National Heart, Lung, and Blood Institute awarded $1.834 million to St. Jude Children's Research Hospital Inc. on July 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to test senescence-targeting therapies for improving hematopoietic stem cell function and mobilization in sickle cell disease. The research addresses pathologic bone marrow stress in sickle cell disease patients, which damages and depletes hematopoietic stem and progenitor cells and selects for...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3.119 million on September 18, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate computational and clinical tools for understanding pain variability in sickle cell disease. The funded work constitutes a prospective cohort study enrolling 1,250 individuals aged 15 years and older living with sickle cell disease in the United States. Over three years, the research...
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $873,449 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to evaluate modern pharmacotherapy treatment regimens and prophylaxis for reducing infections in sickle cell disease. The recipient will conduct a population-based retrospective cohort study leveraging the Sickle Cell Data Collection Network (2010–2024) to assess children with sickle cell disease in Georgia,...
The National Heart, Lung, and Blood Institute awarded Duke University $238,516 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct admixture mapping of genetic modifiers in sickle cell disease. The research leverages the National Heart, Lung, and Blood Institute's TOPMed program, which includes multiple cross-sectional adult sickle cell disease cohorts totaling more than 4,000 participants with whole genome sequencing data and extensive clinical information. The study aims to identify genetic modifiers that explain clinical variability in sickle cell disease presentation and progression of end-organ damage, including priapism, pulmonary hypertension, sickle cell nephropathy, acute chest syndrome, and vaso-occlusive crises. The research team will employ ancestry-aware and transcriptomic imputation analytic approaches to increase statistical power beyond standard genome-wide association studies and improve replication of genetic modifiers across study populations. Duke University's Office of Research Administration serves as the recipient. Work is performed in Durham, North Carolina. The period of performance runs from August 1, 2026, through July 31, 2028. This is a Project Grant, an assistance type providing support for a discrete, time-limited research project.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $238.5k | 8/3/26 |