Project Grant P30GM165333
- The National Institute of General Medical Sciences, under the Department of Health and Human Services National Institutes of Health, awarded the University of Delaware $392,495 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of extracellular vesicle biogenesis and uptake. The research examines how cells release distinct extracellular vesicle subpopulations and how those vesicles mediate intercellular transport of bioactive...
- The National Heart, Lung, and Blood Institute awarded the University of Delaware $395,382 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of visceral adipose tissue in obesity-induced endothelial dysfunction. The research, performed in Newark, Delaware, deciphers how visceral adipose tissue impairs KIR2.1 channels—critical mediators of endothelium-dependent vasodilation—by examining a mechanism involving endothelial CD36. The project...
- The National Institute of General Medical Sciences awarded The Nemours Foundation $1.14 million on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support the Delaware Comprehensive Sickle Cell Research Center (DE SCD COBRE) in Phase 3 funding. The award funds continued operation of a biomedical research center focused on sickle cell disease care and research development. The center recruits and develops sickle cell researchers across multiple...
- The National Institute of General Medical Sciences awarded the University of Delaware $460,953 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate subcellular transport, regulation, and function of RNAs during early development. The research addresses how specific RNAs are transported to the mitotic spindle and what functions proteins encoded by localized transcripts perform during rapid early cleavage divisions in animal embryos. The funded...
- The National Institute of General Medical Sciences awarded the University of Delaware $479,532 on August 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemical methods for the synthesis of complex nitrogen-containing small molecules essential to modern pharmaceuticals. The award funds research on electrophilic nitrogen chemistry to create new synthetic methods that rapidly prepare structurally and topologically complex organic molecules. The...
- The National Heart, Lung, and Blood Institute awarded the University of Virginia $776,745 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to define and target DELE1-mediated mitochondrial stress signaling in cardiomyopathy. The research addresses how mitochondrial dysfunction drives cardiovascular disease, including heart failure and ischemic injury, by characterizing the molecular mechanisms through which DELE1 acts as a mitochondrial stress sensor to...
- The National Institute of General Medical Sciences (NIGMS) awarded the University of Delaware $1,355,976 on April 1, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to investigate ADAM-ephrin interactions in cell signaling and adhesion. The research examines how members of the disintegrin metalloproteinase (ADAM) family shed ephrin B ligands in response to ephrin receptor binding, with the goal of understanding downstream effects on cell signaling and...
- The National Institute of General Medical Sciences awarded the Board of Regents of the University of Nebraska $1,173,748 on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support Phase 3 of the Nebraska Center for Integrated Biomolecular Communication (NCIBC). NCIBC advances understanding of biomolecular communication pathways that regulate cellular functions and coordinate intercellular actions, with application to disease mechanisms and targeted...
- The National Institute of General Medical Sciences awarded the University of Miami $501,165 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and biophysical research on three human membrane proteins with significance to cardiovascular health, hemostasis, and inflammation. The funded research determines the structures and functional mechanisms of connexin channels, which coordinate electrical and metabolic activity in cardiac...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of Maryland Baltimore County $471,305 on September 15, 2026, under the Engineering program (CFDA 47.041) to develop a microfluidic model and metabolomic analysis framework investigating why diabetic patients face elevated cardiovascular disease risk despite controlled blood glucose levels. The project will construct a laboratory model using real human artery tissues...
The National Institute of General Medical Sciences awarded the University of Delaware $1.2 million on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support Phase III of the Center of Biomedical Research Excellence in Cardiovascular Health. The Center continues multidisciplinary research aimed at understanding mechanisms underlying poor cardiovascular health and developing effective interventions. Prior phases successfully established independent research careers for a cohort of investigators and developed a cardiovascular research core. Phase III work will advance the Center organization and management plan while pursuing mechanistic research on cardiovascular disease causes and consequences, with emphasis on modifiable risk factors prevalent in Delaware, including poor diet, obesity, and physical inactivity. Performance occurs in Newark, Delaware, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/5/26 |