This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports innovative research to enhance regulatory immune cell function and extend kidney allograft survival in non-human primates. The $1,455,073 award to the University of Pittsburgh aims to develop new agents and technologies that selectively promote dendritic cell tolerogenicity and regulatory T cell function, with the goal of allowing immunosuppressive drug withdrawal in kidney transplant recipients. The 5-year project incorporates studies on myeloid cell checkpoint agonists, dendritic cell-targeted nanobiologics, and adoptive transfer of autologous regulatory dendritic cells pulsed with donor-derived extracellular vesicles. The award also funds research on modulating inflammation, eliminating donor-reactive memory T cells, and expanding antigen-specific regulatory T cells to achieve durable donor-specific immune regulation. The project leverages specialized cores for transplant pathology, tissue imaging, and nanotechnology to support the comprehensive research objectives.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.5m | 7/3/25 |