Project Grant P01AG090268
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to determine the functional significance of microglial FOXO3 in Alzheimer's disease (AD). The $475,377 award, effective from September 5, 2025 to August 31, 2027, will be used by the awardee, The Trustees of Columbia University in the City of New York, to conduct research on the role of the FOXO3 gene and associated IFN-I signaling pathways in microglial cells and their contribution to AD...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
- This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- The National Institute on Aging (NIA), under the Department of Health and Human Services, awarded a $852,273 Project Grant titled "Genetic Mapping of M6A and Pseudouridine RNA Modifications in the Aging Human Brain and Their Impact on Alzheimer's Disease" to The Trustees of Columbia University in the City of New York. The project, which runs from September 1, 2025 to May 31, 2030, aims to investigate the role of RNA modifications in Alzheimer's disease through an innovative integration...
- The federal Project Grant award of $3,642,232.00, awarded on August 5, 2025 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to leverage genetics and multi-omic data to identify causal genes, cell types, and molecular mechanisms underlying Alzheimer's disease (AD). The project, titled "UNRAVELING THE GENETIC BASIS OF MOLECULAR FUNCTIONS IN ALZHEIMER'S DISEASE", will integrate multi-ancestry molecular quantitative trait loci (xQTL) data...
- This $2,957,210 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the role of CD44-expressing astrocytes in Alzheimer's disease (AD) pathology. The award supports a 4-year research project undertaken by the Trustees of Columbia University in New York. The key objectives are to: 1) elucidate the signaling mechanisms by which CD44 alters astrocyte phenotype and function in vitro, and 2) investigate the impact of astrocytic CD44 on...
- This $3,145,300 federal Project Grant award was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate how the ubiquitin-proteasome system (UPS), specifically the proteasome complexes, are affected in Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and Parkinson's disease. The research aims to elucidate the regulation of the proteasome complex, a key component of protein homeostasis, and its potential role in the pathogenesis of...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $749,030 to The Trustees of Columbia University in the City of New York to conduct research on the mechanisms connecting calcium signaling and autophagy defects in Alzheimer's disease (AD) neurons. The goal is to understand how dysregulation of neuronal calcium (Ca2+) signaling drives impaired autophagy, a key pathological process in AD. The research will evaluate the effects of...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
This Project Grant award, totaling $3,184,272.00 and awarded on Sep 15, 2025 by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research on the role of the SORL1 gene in the pathogenesis and pathophysiology of Alzheimer's disease. The primary awardee, The Trustees of Columbia University in the City of New York, will utilize a recently developed prioritization framework to identify SORL1 gene variants most likely to be pathogenic. The project's cores will provide biomaterials, clinical evidence, and cellular data on the pathogenicity of each variant, integrating structural, cellular, anatomical, and biofluidic investigations. The overall goal is to clarify SORL1's loss-of-function and its impact on the retromer-dependent endosomal recycling pathway, with the aim of expanding the mechanistic understanding of how SORL1 may drive or modulate Alzheimer's disease pathology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 9/5/25 |