Project Grant P01AG026467

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $644,881 to the University of Texas Health Science Center at Houston to investigate a novel blood substitution therapy for treating acute ischemia in the aged brain. The key goals are to evaluate the ability of this therapy to improve outcomes after stroke in aged mice by removing neutrophils and matrix metalloproteinase-9 (MMP-9) from the blood, thereby preserving mitochondrial membrane protein...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,000.00 to the University of Texas Health Science Center at Houston (UTHealth) to conduct research on the relationship between cerebral small vessel disease, ischemic stroke, and sex-specific outcomes. The key objectives are to: Examine the chronic and evolving neurological consequences of small vessel disease following stroke in male and female mouse models, using longitudinal...

Yale University received a $4,705,470 Project Grant award from the National Institutes of Health National Institute on Aging to develop innovative strategies to therapeutically target and image various vascular cellular components to improve understanding of mechanisms leading to dementia. Specifically, the grant will fund proof-of-concept studies focusing on potential cytotoxicity mechanisms related to iron metabolism and reactive oxygen species that may cause microvascular degeneration. The...

The Oregon Health & Science University was awarded a three-year, $3.956 million project grant from the National Institutes of Health National Institute on Aging under the Aging Research program (CFDA 93.866). The grant will support research into the role of G protein-coupled receptor 39 in age-related vascular cognitive impairment. Specifically, the university researchers will test the hypothesis that endothelial-pericyte EET/GPR39 signaling plays a protective role against aging- and small...

This $440,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Northwestern University to investigate how aging affects neutrophil persistence and function following ischemic stroke. The two-year study, running from May 2024 to April 2026, aims to elucidate the role of the transcription factor NR4A2 in driving prolonged neutrophil presence and impaired neutrophil performance in the ischemic brain of aged mice compared to younger mice....

This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, seeks to facilitate the primary investigator's transition to independence as a physician-scientist studying the molecular mechanisms underlying brain injury that occurs after a cardiac arrest. The $224,424 award will support the investigator's research to assess age-related...

The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,387,438 under the Aging Research program (CFDA 93.866) to The Ohio State University Office of Sponsored Programs on September 19, 2022. The three-year project grant aims to develop and test a novel neuroprotective agent, TAT-M2NX, to provide both acute and sustained synaptic protection following acute ischemic stroke. The research seeks to characterize the agent's...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $472,500.00 to the J. David Gladstone Institutes to conduct research on the use of hypoxia (low oxygen) therapy to treat mitochondrial diseases. The project builds on the awardee's previous findings demonstrating that hypoxic breathing can prevent and reverse neurological damage in a mouse model of mitochondrial electron transport chain deficiency. This research will further investigate the...

The University of Rochester received a $423,500 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) to investigate the role of mitochondrial dysfunction and oxidative stress in the progression of tau pathology in Alzheimer's disease. The two-year project will utilize novel optogenetic tools to spatiotemporally control mitochondrial function and reactive oxygen species production in both ex vivo brain slice cultures and an in vivo mouse model of tau...

The National Institute on Aging awarded a $1,931,965 Project Grant (CFDA 93.866 - Aging Research) to the Regenerative Research Foundation to develop and validate a novel 3D human cell model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, pericytes, and microglia derived from induced pluripotent stem cells (iPSCs). The goal is to create an improved model for studying the cerebrovascular interactions underlying Alzheimer's disease-related dementias (ADRD), as current...