Project Grant N000142512246

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), provides $559,820.00 to the University of South Carolina to conduct research on the biomechanics of the human brain during high-severity impacts. The goal is to improve the understanding of traumatic brain injury (TBI) by integrating complementary experimental techniques, including...

This $3,102,638 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop novel gyrencephalic animal models to study the complex neuropathological and clinical features of post-traumatic brain injury (TBI)-induced Alzheimer's disease and related dementias (ADRD). The grant supports an iterative effort to create preclinical swine models that can recapitulate the diverse neuropathologies and symptomatology observed in the chronic phase...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program provides $367,261 to develop an experimentally-validated computational model of how spreading depolarization disrupts the glymphatic system in the brain. The model will simulate the effects of spreading depolarization, which occurs after acute neurological conditions, on the...

This National Science Foundation Project Grant, awarded under the Engineering program (CFDA 47.041), provides $206,132 to Louisiana State University to conduct fundamental research on the high strain rate mechanics of the human brain. The research aims to develop advanced computational models and experimental techniques to better understand the complex mechanical behavior of the living human brain under extreme loading conditions, such as those encountered during traumatic brain injuries. The...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) federal grant program, awarded a $389,813 Project Grant (R21EB034428) to the University of California, Los Angeles (UCLA) for a project titled "Predicting Recovery After TBI: Development and Comparison of MR-Supplemented Models Using Non-Parametric and Machine Learning Multimodal Fusion." The project...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $183,402 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Worcester Polytechnic Institute (WPI) to develop subject-specific computational models for studying sex differences in brain strain and axonal damage related to concussion and subconcussion injuries. The project aims to characterize how male and female brain biomechanics and axonal...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $444,125 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of Virginia (UVA) to conduct research on the relationship between penetrating brain injury, toxic metal exposure, and the development of post-traumatic epilepsy. The study aims to determine whether the duration of exposure to retained metal fragments, such as copper and lead, in...

The National Science Foundation (NSF) awarded The Johns Hopkins University a 3-year, $274,297 Project Grant under the Engineering program (CFDA 47.041) to conduct collaborative research on the extreme mechanics of the human brain. The research aims to generate insights into how the living human brain responds to large and rapid loading, which is critical for developing models to predict traumatic brain injury and designing safer protective equipment. The project will combine high-rate...

This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...

The Lovelace Biomedical Research Institute will receive $734,613 through a Cooperative Agreement award from the Department of the Army Medical Command to quantify the sensitivity and specificity of point-of-care biomarkers in a large-animal model of mild traumatic brain injury. The funding is provided under the Military Medical Research and Development program (CFDA 12.420) to support basic, applied, and advanced biomedical research that transforms healthcare for service members and the...