Project Grant N000140910998

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $589,483 to Wayne State University to assess in vivo changes in central neuronal activation, molecular indicators of synaptic transmission, and motor function in response to vestibular nerve hypofunction generated by noise exposure. The project aims to evaluate the contributions of...

This federal Project Grant award of $448,687, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to investigate the role of calcium regulation in outer hair cells (OHCs) and their sensitivity to cochlear injury. The research aims to enhance understanding of the mechanisms that protect OHCs, which act as sentinels of cochlear injury, from damage due...

This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $149,804.00 to The Jackson Laboratory to study the role of the ACO2 gene in progressive hearing loss. The key goals of this 3-year research project are to: 1) Track spiral ganglion neuron (SGN) defects in ACO2 R56L mutant mice from developmental stages to young adulthood; 2)...

This Project Grant award of $187,510 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to investigate the mechanisms and clinical impact of neo-ossification (new bone formation) following cochlear implantation. The key objectives are to: 1) leverage advanced imaging techniques to assess in-vivo cochlear neo-ossification in human and mouse cochlear implant recipients, 2)...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $275,371 Project Grant (CFDA 93.173) to Auricle Health Inc. to develop an extracochlear device to restore hearing for patients with sensorineural hearing loss (SNHL). The funding will support refinement of the electrode design, demonstration of electrical stimulation of the cochlear nerve in animal models, and evaluation of the long-term safety and durability of the implant. This project aims to create a...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to investigate the mechanisms underlying the olivocochlear system's ability to enhance cochlear function in mice. The $416,642 award, valid from July 2024 to June 2026, will enable researchers at the University of Rochester to: 1) isolate and systematically evaluate the...

This federal Project Grant award of $673,048 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The objective is to investigate the role of mitochondrial calcium regulation in cochlear hair cells and its contribution to acquired hearing loss, with a focus on assessing the impact of acoustic overstimulation and developing strategies to mitigate noise-induced...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $131,555 to Oregon Health & Science University (OHSU) for a 2-year period from July 1, 2025 to June 30, 2027. The project aims to investigate how noise-induced hearing loss (NIHL) affects the central auditory processing of natural sound categories in the auditory cortex. Key...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $147,486 to Emory University to study the neural mechanisms underlying recovery of sound localization after unilateral hearing loss in mice. The research aims to determine how changes in neural activity in the auditory cortex and inferior colliculus drive behavioral recovery of...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA 93.173 Research Related to Deafness and Communication Disorders program, provides $296,536 to Purdue University to investigate the physiological roles of the medial olivocochlear (MOC) efferent pathways and their impact on hearing in noise. The research aims to enhance understanding of the MOC system's input pathways, especially from the inferior colliculus, and how...