This $416,642 Project Grant award from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports research to investigate the mechanisms underlying the enhancement of cochlear function mediated by the medial olivocochlear (MOC) system in mice. The key objectives are to: 1) isolate and systematically evaluate the MOC-mediated enhancement phenomenon by pharmacologically blocking and genetically ablating the...
This $369,806 Project Grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders will fund research into objective screening tests for noise-induced hearing damage. The University of Wisconsin-Madison will investigate short- and long-term changes in cochlear, afferent, and efferent auditory system function due to noise exposure using otoacoustic emission-based assays of the middle ear muscle reflex and medial olivocochlear reflex....
The National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders Federal Grant Program (CFDA 93.173), awarded a $417,741 project grant to the Massachusetts Institute of Technology (MIT) to develop computational models that replicate human auditory abilities. The goal is to improve prosthetic devices and therapeutic interventions for individuals with hearing impairment, cochlear implants, and auditory...
This $194,400 Project Grant awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 - Research Related to Deafness and Communication Disorders, will support research by the Massachusetts Eye and Ear Infirmary to investigate the role of perineuronal nets (PNNs) and microglia in the dysfunction of parvalbumin-positive interneurons (PVIs) that contributes to hyperacusis and other suprathreshold hearing disorders following sensorineural hearing loss....
This $623,777 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders Program (CFDA 93.173), supports research focused on understanding the role of the immune system and inflammation in hearing loss. The primary awardee, The Washington University, will investigate how viral infections like cytomegalovirus (CMV) impact the development of the blood-labyrinth barrier in the inner ear,...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $137,305 Project Grant (CFDA 93.173 - Research Related to Deafness and Communication Disorders) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant supports research to determine the mechanisms by which cortico-fugal neurons enable contextual processing in the auditory system, investigate if top-down inputs alter context-dependent...
This federal Project Grant award of $722,677, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), is aimed at improving the diagnosis and understanding of otitis media with effusion (OME) and its related hearing loss in children. The primary objectives are to: 1) develop a non-invasive objective estimate of hearing loss due to OME, 2) characterize the short-term...
The National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders Federal Grant Program (CFDA 93.173), awarded a $662,162 Project Grant (R01DC022777) to Oregon Health & Science University (OHSU). The grant, with a period of performance from April 4, 2025 to March 31, 2030, aims to investigate binaural fusion and integration of spectral and temporal information in individuals with hearing loss, including those...
This federal Project Grant award of $618,956 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to determine how cholinergic signaling in the inferior colliculus of the auditory midbrain drives adaptive sound processing and how this is altered in disorders like auditory gating, hearing loss, and aging. The key products and services to be delivered under this...
This $676,533 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to elucidate the genetic underpinnings of adult-onset hearing loss. The principal investigator at the University of Pennsylvania will leverage genome sequencing and mouse models to identify genomic targets of the ZFP719 gene and determine how its misregulation impacts...
This $221,484 Project Grant award from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports a research project at Purdue University investigating the physiological roles of the medial olivocochlear (MOC) efferent pathways and their impact on hearing in noise.
The project aims to enhance understanding of the MOC system's role in listening in noise and the effects of sensorineural hearing loss, with the goal of informing improvements to hearing aid algorithms. The research involves innovative physiological methods to isolate and manipulate individual MOC pathways, including exploring the role of the inferior colliculus input, investigating the cochlear nucleus input, and examining the effects of hearing loss on MOC output projections. The findings are expected to significantly advance knowledge of the MOC efferent system and have broader implications for improving hearing aids and technologies for individuals with communication disorders.