Project Grant K99NS140499
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop a closed-loop system for preventing Sudden Unexpected Death in Epilepsy (SUDEP) by regulating the functions of the dorsal raphe nucleus. The $385,091 award, effective from August 7, 2025 to July 31, 2030, will be administered by The Ohio State...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to Dr. Nicholas Burgraff to conduct research aimed at understanding the neurophysiological mechanisms by which opioids disrupt respiratory function and lead to airway constriction. The research seeks to identify new therapeutic approaches to mitigate the life-threatening respiratory complications of opioid overdose. The award will...
- This $357,191 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to mechanistically link acute seizures with chronic alterations in cholinergic networks in a mouse model of Dravet syndrome. The primary objective is to delineate seizure-associated pathology in the cholinergic pedunculopontine nucleus (PPN) to identify targets for...
- This Project Grant award of $425,050 from the U.S. Department of Health and Human Services' National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) supports research related to the long-term effects of acute organophosphate intoxication. The key objectives are to: 1) evaluate the natural history, 2) elucidate mechanisms related to long-term effects like spontaneous recurrent seizures and cognitive dysfunction, 3) identify relevant biomarkers, and 4) identify new...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) in the amount of $106,474 supports research to understand how endogenous opioids influence the development of respiratory neurons and breathing patterns during early life. The research aims to determine how endogenous opioids impact the physiology and morphology of developing brainstem respiratory neurons, as well as how mu-opioid receptors and endogenous opioid peptides...
- This Project Grant award, titled "State-Dependent Connectivity of Impaired Autonomic Brain Networks Underlying Cardiorespiratory Dysfunction in Epilepsy", is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $147,486 award will be used by Vanderbilt University to investigate how disruptions in neural circuits involved in cardiorespiratory and...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $586,377 to Rutgers, The State University to conduct research on the role of the immune kinase RIPK3 in modulating neuronal excitability and providing neuroprotection during viral encephalitis and excitotoxic stress. The 5-year project, awarded on August 1, 2025, aims to...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded a $449,391 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Florida to study combinatorial respiratory rehabilitation approaches to enhance breathing recovery after cervical spinal cord injury. The project aims to maximize breathing recovery in patients with chronic, incomplete...
This $123,349 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rutgers, The State University of New Jersey to investigate the convergent mechanisms by which seizures and alcohol poisoning affect breathing. The key objectives are to determine how increases in adenosine signaling triggered by seizures and alcohol poisoning suppress serotonergic and noradrenergic neurons that regulate respiration, potentially leading to respiratory arrest. The research utilizes cutting-edge fiber photometry techniques in rodent models to differentiate the direct effects of adenosine on respiratory circuits from indirect effects mediated by changes in blood gases. The findings aim to inform the development of novel treatment strategies to mitigate the significant mortality associated with respiratory dysregulation caused by seizures and alcohol poisoning.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.3k | 7/30/25 |