Project Grant K99NS112412

This four-year, $1.96 million project grant from the National Science Foundation's Office of Emerging Frontiers and Multidisciplinary Activities, under the Engineering program (CFDA 47.041), will develop improved brain-machine interface algorithms to restore movement and speech abilities. The University of California, San Diego will apply advances in understanding biological motor control to design decoding strategies enabling robust prosthetic control across contexts. Existing feedforward...

The National Institute of Neurological Disorders and Stroke awarded the University of Kansas Medical Center Research Institute $580,517 on September 3, 2026, to examine neural features that improve brain-computer interface precision and reliability under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The recipient will conduct three experiments to improve BCI decoders that translate neural signals into reaching and grasping when task...

The National Institute of Neurological Disorders and Stroke awarded Trustees of Boston University $159,104 on February 12, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect how primary motor cortex flexibly controls different types of movements in macaque monkeys. The research tests the hypothesis that motor cortex activity during reaching is controlled primarily by strong recurrent dynamics within the cortex, whereas...

The National Science Foundation (NSF) Division of Behavioral and Cognitive Sciences awarded a $500,000 Project Grant to the University of California, Davis (UC Davis) to understand how the brain supports decision-making processes. The three-year grant, awarded under the NSF's Social, Behavioral, and Economic Sciences program (CFDA 47.075), aims to identify neural features that provide information about the decision-making process, build decoders to predict decisions, and develop a closed-loop...

The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $117,145 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on the neural dynamics underlying self-generated action decisions under uncertainty. The research investigates how the brain determines when and where to act in...

The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $150,932 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop computational and theoretical models characterizing interactions between motor cortex and dorsolateral striatum in naturalistic motor behavior. The project uses simultaneous multi-region neural recordings from mice combined...

The National Science Foundation Division of Molecular and Cellular Biosciences awarded the Trustees of Boston University $1,035,226 on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate how populations of neurons across multiple brain areas coordinate to mediate flexible decision-making—the process of combining sensory evidence and context to select appropriate actions toward behavioral goals. The research examines neural dynamics underlying perceptual...

The National Institutes of Health (NIH) awarded a $1,385,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization, to develop novel techniques for measuring the input-output operations of individual neurons in the mouse cortex. The project aims to overcome challenges in understanding how neurons in the mammalian brain transform their synaptic inputs into outputs, which is critical for designing effective brain-machine...

The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $394,915 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate and augment cholinergic signaling for enhanced neuroprosthetic performance. The research targets mechanisms that accelerate learning and control of brain-computer interfaces (BCIs) for paralyzed patients. Current intracortical neuroprosthetic implants have...

The National Science Foundation Division of Computing and Communication Foundations awarded the University of Rhode Island $528,114 on October 1, 2026, under the Computer and Information Science and Engineering program (CFDA 47.070) to advance brain-computer interfaces for upper-limb prosthetic control. The award funds a collaborative research project running through September 30, 2029, performed at the University of Rhode Island in Kingston, Rhode Island. The project develops non-invasive...