Project Grant R01NS150468
- The National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) awarded $361,125 to the University of California, Berkeley on September 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) as a project grant. The award funds a targeted planning project to establish a functional connectomics paradigm combining ultra-fast two-photon voltage imaging (2P-FACED) with two-photon optogenetic...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $478,336 on August 15, 2026, to investigate cortico-cerebellar interactions underlying goal-directed actions under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will examine how neural circuits in the brain, specifically interactions between the anterior lateral motor cortex and the cerebellum, give rise to goal-directed movement planning...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $117,145 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on the neural dynamics underlying self-generated action decisions under uncertainty. The research investigates how the brain determines when and where to act in...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $120,582 to President and Fellows of Harvard College on January 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating motor learning mechanisms in cortico-basal ganglia circuits. The project explores how neural circuits generate behavioral...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, assistance type: Project Grant F31NS149497). The project investigates cell-type-specific contributions of the primary somatosensory cortex to skilled forelimb control using two-photon calcium microscopy, optogenetic perturbation, genetic access to projection neuron types...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $394,915 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate and augment cholinergic signaling for enhanced neuroprosthetic performance. The research targets mechanisms that accelerate learning and control of brain-computer interfaces (BCIs) for paralyzed patients. Current intracortical neuroprosthetic implants have...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded Drexel University $547,255 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of the functional organization of descending neuron networks that control collision-avoidance behavior. Using electron microscopy connectomes of the central nervous system at synaptic...
- The National Institute of Neurological Disorders and Stroke awarded Trustees of Boston University $159,104 on February 12, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect how primary motor cortex flexibly controls different types of movements in macaque monkeys. The research tests the hypothesis that motor cortex activity during reaching is controlled primarily by strong recurrent dynamics within the cortex, whereas...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,077 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop next-generation tools for human cortical cartography. The award funds generation of a multi-modal atlas of human cortical areas with improved accuracy beyond the 2016 version, characterization of individual variability and subareal organization within cortical...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $150,932 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop computational and theoretical models characterizing interactions between motor cortex and dorsolateral striatum in naturalistic motor behavior. The project uses simultaneous multi-region neural recordings from mice combined...
The National Institute of Neurological Disorders and Stroke awarded the University of Kansas Medical Center Research Institute $580,517 on September 3, 2026, to examine neural features that improve brain-computer interface precision and reliability under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The recipient will conduct three experiments to improve BCI decoders that translate neural signals into reaching and grasping when task conditions change. Aim 1 investigates how combinations of wrist orientation and hand shape affect grasping, testing whether reaching and grasping are object-centric with grasp determined first and reach adjusted accordingly. Aim 2 will evaluate BCI decoders designed to enhance movement timing and speed profiles to resemble natural motion, testing whether condition-invariant neural activity improves movement timing and whether the primary motor cortex best provides these signals. Aim 3 will examine neural tuning to novel reach directions similar to previously learned ones, testing whether increasing the number of neural dimensions used improves decoding accuracy compared to traditional linear decoders. Recordings will be taken from the primary motor cortex, premotor cortex, anterior intraparietal area, and parietal reach region. Analyses will range from single-neuron firing rates to advanced neural population models. The experiments will identify BCI-relevant neural features preserved across tasks and clarify how population-level activity supports consistent reaching and grasping under varying conditions. Work is performed in Kansas City, Kansas, with a period of performance from September 3, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $580.5k | 9/3/26 |