Project Grant K99HL177177
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to Dr. Nicholas Burgraff to conduct research aimed at understanding the neurophysiological mechanisms by which opioids disrupt respiratory function and lead to airway constriction. The research seeks to identify new therapeutic approaches to mitigate the life-threatening respiratory complications of opioid overdose. The award will...
- This Project Grant award of $497,628.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into pulmonary vagal sensory neurons and their role in breathing abnormalities associated with bronchopulmonary dysplasia (BPD) in preterm infants. The research aims to elucidate the dose- and duration-dependent effects of neonatal hyperoxia exposure on breathing control and the functional roles of distinct populations of...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $671,732.00 to The Washington University to conduct research on the mechanisms underlying fentanyl-induced cardiorespiratory depression. The project aims to evaluate peripherally-acting mu opioid receptor antagonists as a potential treatment strategy to reverse opioid-induced respiratory depression without precipitating withdrawal or aversion, which is a...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $495,950 to The Washington University in Missouri to investigate the mechanisms involving mu opioid receptor (MOR) signaling within the nucleus of the solitary tract (NTS) that contribute to fentanyl-induced cardiorespiratory depression. The 3-year project, commencing on Sept 1, 2025, aims to employ various techniques such as chemogenetics, optogenetics, and...
- This $673,512 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing rhythms. The project aims to determine whether the subconscious breathing rhythm arises from an autonomous oscillator or reciprocal inhibition between key neuronal populations in the brainstem. UCSF will use advanced mouse...
- This Project Grant, awarded by the National Institute on Drug Abuse (NIDA), will fund research to develop an advanced optical device that can quantify cerebral oxygenation and blood flow in infants with prenatal opioid exposure. The $251,006 award will support a 2-year study (7/15/2025 - 6/30/2027) to acquire longitudinal data on cerebral physiology in the first week of life for this population and evaluate associations with short-term clinical outcomes. The proposed hybrid device that...
- This federal Project Grant award, valued at $744,305 and awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports a research project titled "Molecular Physiology of PHOX2B-Expressing RTN Chemoreceptor Neurons" at the University of Virginia. The research examines gene regulatory functions of the PHOX2B transcription factor and its relevance for the function and connectivity of retrotrapezoid nucleus...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $421,800 to Midwestern University to explore the effects of chronic intermittent hypoxia on cholinergic modulation at hypoglossal motoneurons. The project aims to determine changes in muscarinic acetylcholine receptor expression and cholinergic inputs to hypoglossal motoneurons in neonatal and adult mice exposed to chronic...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $166,395 to Columbia University to conduct a 5-year research project on the impact of hyperoxia (excess oxygen) on the function of respiratory progenitor cells in neonates. The project aims to develop a better understanding of the mechanisms by which post-natal lung development occurs in the face of injurious agents like oxygen...
- This $146,703 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the cellular and molecular mechanisms underlying respiratory control dysfunction in hypertension. The principal investigator will use electrophysiology and imaging approaches to study the role of the retrotrapezoid nucleus (RTN) in regulating the respiratory response to changes in CO2/H+ in spontaneously hypertensive rats. The...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) in the amount of $106,474 supports research to understand how endogenous opioids influence the development of respiratory neurons and breathing patterns during early life. The research aims to determine how endogenous opioids impact the physiology and morphology of developing brainstem respiratory neurons, as well as how mu-opioid receptors and endogenous opioid peptides influence breathing during development. This will be investigated using mouse models with whole-body deletion of mu-opioid receptors and the opioid peptide enkephalin, leveraging brain slice electrophysiology, immunohistochemistry, and breathing assessments in awake mice. The findings may reveal novel strategies for improving breathing in newborns experiencing respiratory conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $106.5k | 8/29/25 |