This Project Grant award, valued at $671,732, was issued by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The purpose of the award is to evaluate the use of peripherally-acting mu opioid receptor (MOR) antagonists to prevent and reverse fentanyl-induced respiratory depression, a major cause of opioid overdose deaths, while minimizing withdrawal and aversion side effects. Key objectives include assessing peripheral MOR mechanisms contributing to opioid-induced respiratory depression, and investigating the role of vagal afferent inputs to the nucleus of the solitary tract in this process. The award was granted to The Washington University in St. Louis, a prominent private research institution, to conduct this research from May 1, 2025 through April 30, 2028. The findings have the potential to inform the development of new, life-saving treatments for fentanyl overdoses.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $671.7k | 4/30/25 |