Project Grant K08HL166967
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will fund a study on the early life predictors of airway-to-lung mismatch, a condition known as dysanapsis. The primary awardee, The Trustees of Columbia University in the City of New York, will receive $753,018 to leverage longitudinal data from 8 diverse birth cohorts to examine the relationship between early-life exposures, such...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $594,583 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia (CHOP) Research Institute. The grant supports research to investigate the mechanisms regulating the development, expansion, and decline of neonatal lung myofibroblasts and their role in alveologenesis. Key objectives include utilizing a novel murine model to study myofibroblast lineage, characterize...
- This federal Project Grant award for $637,913, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research by the University of Southern California (USC) to investigate the role of "transitional alveolar epithelial cells" in lung development and regeneration. The goal is to better understand the mechanisms underlying the alveolar epithelial cell differentiation process during normal lung development, as...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $701,795 to The Trustees of the University of Pennsylvania to conduct research aimed at defining the cardinal functions of lung progenitors during regeneration. The 4-year project, which began in September 2025, utilizes a multi-modal approach including cell lineage tracing, single-cell analysis, histological spatial analysis, and cross-species comparison to...
- This federal Project Grant award, funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the role of the hedgehog pathway and primary cilia axis in human lung alveologenesis and diseases such as bronchopulmonary dysplasia (BPD). The $156,168 grant awarded to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center will fund a 2-year study examining the cellular and molecular...
- This $480,990 Project Grant awarded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) aims to establish the central role of a recently identified lung cell type, "aerocytes," in regulating alveolar regeneration following lung injury. The research proposal has two key objectives: Investigate the role of aerocyte-derived R-spondin3 in lung growth and recovery using animal studies within disease-related lung injury models....
- This Project Grant award of $497,628.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into pulmonary vagal sensory neurons and their role in breathing abnormalities associated with bronchopulmonary dysplasia (BPD) in preterm infants. The research aims to elucidate the dose- and duration-dependent effects of neonatal hyperoxia exposure on breathing control and the functional roles of distinct populations of...
- This $721,826 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to identify molecular mechanisms regulating alveolar matrix fibroblast function and their role in supporting vascular capillary formation. The research is being conducted by Children's Hospital Medical Center in Cincinnati, Ohio to advance the understanding of alveolar septation and septal wall maturation, which is...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will support research into the role of post-transcriptional RNA modifications in lung development and regeneration. The $768,985 award, effective September 1, 2025 through June 30, 2029, will enable researchers at Columbia University's Health Sciences Division to study how the METTL3/14 complex-mediated RNA modifications, including on the SOX9 transcript, regulate lung...
- The National Heart, Lung, and Blood Institute (NHLBI), via the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $564,445 Project Grant to the University of Texas Health Science Center at Houston (UTHealth) to fund research on "Targeting Hypoxia-Inducible Factors (HIFs) for Heart and Lung Disease." The 6-year grant, starting on March 1, 2025 and ending on December 31, 2031, supports three complementary research projects focused on investigating the upstream regulation...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $166,395 to Columbia University to conduct a 5-year research project on the impact of hyperoxia (excess oxygen) on the function of respiratory progenitor cells in neonates. The project aims to develop a better understanding of the mechanisms by which post-natal lung development occurs in the face of injurious agents like oxygen and mechanical ventilation, with the goal of informing future therapies to promote healthy and functional lung growth. The principal investigator, an assistant professor in pediatric pulmonology, will receive mentorship from established researchers in the fields of lung injury/repair and early lung development to build interdisciplinary and translational research skills. The findings from this project may contribute to advancing the treatment of bronchopulmonary dysplasia, a chronic lung disease affecting premature infants.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $166.4k | 8/20/25 |