Project Grant K99HG013547

Award Date 8/6/24
Completion Date 7/31/26
Dollars Obligated $152K
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
New York, USA
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This Project Grant award from the National Human Genome Research Institute (NHGRI), part of the Human Genome Research (CFDA 93.172) federal grant program, provides $151,956 to fund the "PATHFINDER: Finding the Genomic and Clinical Pathways Underlying Heterogeneity in Complex Disease" research program at the Icahn School of Medicine at Mount Sinai. The key objectives of this project are to:

  1. Determine the biological context in which putative causal genes associated with complex diseases like schizophrenia, inflammatory bowel disease, and coronary artery disease operate. This involves identifying the relevant tissues, cell types, and functionally related genes.

  2. Utilize the PRSET software to compute pathway-based polygenic risk scores that can identify shared and distinct genetic profiles across patients, enabling more genetically and clinically homogeneous disease subgroups to be stratified.

  3. Develop a precision medicine framework to stratify patients from large biobanks based on the polygenic risk scores and their associations with clinical factors and disease symptoms.

This research program aims to advance the understanding of disease heterogeneity, leading to more targeted and effective interventions and treatments. The grant period runs from August 6, 2024 to July 31, 2026.

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