Project Grant K99HD123470
- The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center $724,852 on September 1, 2026, under CFDA 93.865 (Child Health and Human Development Extramural Research) to investigate lymphatic pathology caused by dysregulated NFATC1 signaling using Down syndrome as a model. The research will examine how increased dosage of chromosome 21 genes DYRK1A and DSCR1 drives NFATC1 hyperphosphorylation and functional suppression, disrupting lymphatic...
- The National Institutes of Health (NIH) Office of the Director awarded a Project Grant of $1,896,457.00 under the Trans-NIH Research Support program (CFDA 93.310) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for the project "BRAIN DEVELOPMENT IN DOWN SYNDROME DURING FETAL AND EARLY POSTNATAL AGES". The grant, awarded on Sep 18, 2024, aims to confirm earlier findings on brain abnormalities in Down syndrome (DS) using advanced...
- The National Institute of Child Health and Human Development awarded the University of Wisconsin - Madison $122,361 on January 31, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the mechanisms of reduced neuron generation in Down syndrome. The research evaluates how an extra copy of human chromosome 21 causes reduced cortical size and neuron formation during development. The work focuses on neural progenitor cell behavior during...
- The National Institutes of Health Office of the Director awarded Ann & Robert H Lurie Children's Hospital of Chicago $448,860 on August 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to co-design a digital care pathway that improves primary care clinician adherence to pediatric Down syndrome health supervision guidelines. The project will develop a scalable digital pathway to facilitate clinician implementation of evidence-based Down syndrome screening, early treatment,...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $297,252 on September 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment in Down syndrome. The research examines whether placental abnormalities contribute to altered cortical development in individuals with Down syndrome (trisomy 21). The project uses...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- The National Institute on Aging awarded Brigham & Women's Hospital $889,734 on September 1, 2026, under the Aging Research program (CFDA 93.866) to advance care planning for older individuals with Down syndrome experiencing early-onset and accelerated dementia. The award funds a mechanistic evaluation of the Serious Illness Care Program (SICP)—a multi-modal intervention comprising a structured conversation guide and clinician training—tailored to older individuals with Down syndrome facing...
- The National Institutes of Health Office of the Director awarded the University of Southern California $462,951 on July 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to measure real-world stepping and walking performance in infants and toddlers with Down syndrome. The award funds validation of accelerometer-based wearable step-counting devices for infants with Down syndrome, addressing a gap in clinical measurement tools. The project will establish the accuracy of step...
- The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types,...
- The National Institute of Child Health and Human Development awarded Trustees of Boston University $166,752 on April 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a five-year research career development program improving self-management training utilization for individuals with traumatic brain injury. The research employs a hybrid implementation-effectiveness approach to address barriers in transitioning evidence-based self-management...
The National Institute of Child Health and Human Development awarded Trustees of Boston University $131,694 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize neural correlates of motor skill development in children with Down syndrome. The research uses upper extremity reaching as a model motor behavior to identify associations between reaching kinematics and brain activity in two pediatric cohorts. During the two-year mentored K99 phase, 20 children with Down syndrome (ages 7–12) and 20 age-matched typically developing children will complete functional reaching tasks with simultaneous measurement of reaching kinematics using inertial measurement units and neural activity using functional near-infrared spectroscopy. The study will characterize differences in brain-behavior relationships between children with Down syndrome and typically developing children and identify biomarkers to predict motor impairment severity and guide individualized interventions. The investigator will receive training in functional near-infrared spectroscopy and inertial measurement units as research tools for real-world neuromotor assessment. The subsequent R00 phase, following the investigator's transition to a tenure-track faculty role, will longitudinally assess 20 infants with Down syndrome and 20 typically developing infants at two time points (6–12 and 18–24 months) to examine how neural activity changes with developmental progression of reaching skill and assess additional predictors of motor outcomes. Work is performed in Boston, Massachusetts. The period of performance runs through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.7k | 8/19/26 |