Project Grant R21HD120939
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Harvard T.H. Chan School of Public Health $996,169 under the Child Health and Human Development Extramural Research program (CFDA 93.865) on September 15, 2025, with a completion date of June 30, 2030. The award funds the TSEPAMO Next Generation study, which addresses two critical research objectives for pregnant women living with HIV in Botswana: (1) evaluating the safety and efficacy of...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development awarded a $238,168 Project Grant to the President and Fellows of Harvard College (Harvard T.H. Chan School of Public Health) on July 15, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research initiative investigates the relationship between maternal in utero exposure to cardiometabolic medications during the first trimester and the...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $125,142 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) to The Washington University, effective June 1, 2026, through May 31, 2028. The grant funds research investigating the impact of bacterial vaginosis (BV) toxins on sperm function in both mouse and human models. The research aims to elucidate molecular mechanisms by which BV-associated...
- Federal Project Grant Award Summary Trustees of Tufts College received a $351,945 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), with an award date of June 1, 2026, and completion date of February 28, 2031. The research project, titled "Dissecting the Inflammation Resolution Mechanisms in Endometrial Health and Disease," focuses on investigating the role of...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $163,050 Project Grant to the University of Chicago on November 22, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award extends through June 30, 2029, and supports a research initiative titled "Leveraging Enhanced Phenotyping and Causal Inference Approaches to Investigate the Effect of Maternal Medication Exposures on Child...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Columbia University's Health Sciences Division a $719,141 Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) on August 11, 2025, to conduct a longitudinal study leveraging in vitro fertilization (IVF) to identify prenatal programming effects independent of shared maternal-child genes. The research will test the Developmental Origins of Health and...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded UC San Diego a $566,573 Project Grant on August 1, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a five-year individually randomized-controlled trial evaluating point-of-care screening and treatment for Chlamydia trachomatis (CT) infection to prevent preterm birth among asymptomatic pregnant women in Botswana. The study addresses a...
- Federal Grant Award Summary The National Institute of Child Health and Human Development awarded the University of Virginia a $1.43 million Project Grant (CFDA 93.865: Child Health and Human Development Extramural Research) on September 17, 2025, to conduct a Phase II clinical trial investigating the treatment of small intestine bacterial overgrowth (SIBO) as a prevention strategy for linear growth stunting and malnutrition in impoverished children in Bangladesh. The award supports research...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $456,500 project grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award, effective June 1, 2026, through May 31, 2028, funds research to characterize the molecular mechanisms of the human cervical epithelium during pregnancy. The primary deliverable involves generating novel...
- Federal Grant Award Summary Beth Israel Deaconess Medical Center, Inc. received a Project Grant award of $164,484 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through July 31, 2030. The award funds a research project titled "Placental NAD and Its Effect on Labor Onset," which investigates the role of nicotinamide adenine dinucleotide (NAD+)...
Harvard T.H. Chan School of Public Health received $357,567 in funding from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) for a project grant awarded June 1, 2026, with completion targeted for February 29, 2028. The research investigates the mechanisms by which vaginal Lactobacillus bacteria promote healthy pregnancies and reduce adverse pregnancy outcomes, including preterm birth and reduced fertility. The project focuses on understanding how anti-inflammatory effectors produced by these bacteria suppress inflammatory signaling pathways in reproductive tissues. The research deliverables encompass both in vitro and in vivo studies designed to characterize the protective mechanisms of Lactobacillus-produced compounds. The project will evaluate whether intravaginal application of these compounds can rescue decidualization markers in human endometrial stromal cells and murine models under inflammatory conditions, suppress inflammatory signaling in placental trophoblast cell lines, and identify immune cell correlates associated with rescue from toll-like receptor (TLR)-induced fetal demise. The work is expected to advance understanding of how microbial metabolites influence pregnancy outcomes and maternal-fetal immune tolerance, with potential implications for therapeutic interventions addressing adverse pregnancy outcomes affecting approximately 10% of pregnancies globally.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $357.6k | 6/1/26 |