Project Grant K99HD122914
- The National Institute of Child Health and Human Development awarded $249,000 to the University of North Carolina at Greensboro on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research dissecting input-output relationships of developmental bone morphogenetic protein (BMP) signaling. The research program employs quantitative imaging techniques, classical genetics, and biochemical approaches to understand how cells produce...
- The National Institute of Child Health and Human Development awarded the University of California, Santa Barbara $123,957 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) for research into how mechanical forces coordinate cell movements during vertebrate gastrulation, specifically examining the Spemann-Mangold organizer's role in establishing germ layers and embryonic axes. The funded research develops and applies...
- The National Institute of Child Health and Human Development awarded The Morgridge Institute For Research, Inc., $131,832 on August 21, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research on appendage regeneration signaling and transcriptional programs. The award funds investigation into how signaling dynamics, transcriptional output, and physiological cues control regenerative growth in zebrafish dermal appendages, using live imaging,...
- The National Institute of Child Health and Human Development awarded The Trustees of The University of Pennsylvania $149,190 on January 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to elucidate the biochemical mechanisms of SCMH1, an accessory subunit of polycomb repressive complex 1, during cellular differentiation. The research investigates SCMH1's role in polycomb-mediated gene repression through RNA-binding and nuclear condensation....
- The National Institute of Child Health and Human Development awarded the University of Pennsylvania $100,228 on January 1, 2027, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate long-lived cardiac myosins as regulators of oocyte cytoskeletal integrity and reproductive lifespan. The research examines how exceptionally long-lived proteins—specifically A- and B-cardiac myosin heavy chain proteins (MHC-A/-B)—maintain oocyte cytoskeletal...
- The National Institute of Child Health and Human Development awarded The Trustees of the University of Pennsylvania $600,000 on August 15, 2026, for Project Grant R01HD120404 under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds investigation of how DNA repeat evolution—transposable elements, telomeric satellites, and centromeric satellites—affects early mammalian embryonic development and genome function. The research uses mouse models to test...
- The National Institute of Child Health and Human Development awarded The Trustees of the University of Pennsylvania $704,336 on August 17, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of T cells in transgenerational epigenetic inheritance. The funded research examines how the immune system, specifically T cells, can epigenetically alter phenotypes across multiple generations of progeny. Preliminary data demonstrates that T...
- The National Institute of Child Health and Human Development awarded The Children's Hospital of Philadelphia $248,999 on September 2, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865). The award funds research training to develop expertise in emotional and biobehavioral mechanisms of parent-infant emotional synchrony. The principal investigator will pursue advanced training in mother-infant electrocardiogram and electroencephalography...
- The National Institute of Child Health and Human Development awarded $119,610 to the University of Pennsylvania on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop generalizable growth charts of thalamocortical development in early childhood. Thalamocortical bundles of white matter regulate critical periods of brain plasticity throughout development, and their disruptions have been implicated in common and debilitating psychiatric...
- The National Institute of Child Health and Human Development awarded California Institute of Technology $128,331 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the hydraulic regulation of human gastrulation and mesodermal patterning using stem cells. The research employs a novel three-dimensional stem cell-based model termed "lumenoids" to dissect mechanobiological principles underlying early...
The National Institute of Child Health and Human Development awarded The Trustees Of The University Of Pennsylvania $134,325 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support a K99 Transition to Independence Award (K99HD122914) investigating mechanisms of bone morphogenetic protein (BMP) signaling through receptor sub-functionalization. The research examines how type I receptor sub-functions regulate BMP signaling by determining how differing sub-domains and protein-protein interactions delineate receptor sub-functions across vertebrate patterning systems. The investigator will leverage the zebrafish model system and human embryonic stem cell gastruloids to interrogate BMP receptor sub-functionalization in different embryonic patterning models, with applications toward understanding normal development and developing disease therapies and directed cell differentiation for tissue engineering. Performance occurs in Philadelphia, Pennsylvania, with a period of performance from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $134.3k | 8/28/26 |