This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 Child Health and Human Development Extramural Research, aims to identify the molecular mechanisms linking lactation to metabolism. The $751,710.10 award, granted on August 15, 2024, will fund investigations to understand the effect of maternal gestational diabetes on mammary epithelial cell (MEC) progenitor insulin signaling and MEC profiles, as...
The National Institute of Child Health and Human Development (NICHD) awarded a $154,796 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Massachusetts Institute of Technology (MIT) to develop a biomimetic, 3D mammary lobe model that can faithfully mirror breast milk synthesis processes and serve as a screening testbed for evaluating the safety of drugs and therapeutics during lactation. The project aims to understand how...
This $128,817 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Regents of the University of Minnesota supports a research project to comprehensively profile the composition of human breast milk and investigate its impacts on infant development. The project aims to identify genetic variants influencing milk metabolites, assess the effects of human cytomegalovirus reactivation in...
The National Institute of Child Health and Human Development (NICHD) awarded a $463,360 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Weill Medical College of Cornell University for a project titled "Maternal Milk Cytokines Activate Cognate Receptors in the Neonatal Esophagus to Program Adult Social Behavior." The research aims to determine how maternal milk cytokines interact with receptors in the neonatal esophagus to influence brain...
The University of Colorado-Denver was awarded a $655,674 Project Grant (Award ID: R01HD117769) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to investigate the role of lipid droplet docking in lactation initiation and milk secretion. The project aims to explore the cellular mechanisms involved in secretory activation, the crosstalk between secretory and myoepithelial cells, and how...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a comparative study investigating the mechanistic effects of human milk feeding on neurodevelopment in preterm infants. The $239,399 award to the Regents of the University of Idaho will utilize a neonatal piglet model to examine how human milk feeding influences intestinal barrier function,...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $756,746 to the Regents of the University of Minnesota to conduct research on the effects of maternal stress on lactation, feeding outcomes, and neurodevelopmental outcomes for preterm infants in the neonatal intensive care unit (NICU). The key activities include: 1)...
Cornell University was awarded a $1,021,609 Project Grant from the National Science Foundation Division of Integrative Organismal Systems. The grant falls under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increased knowledge and understanding of major challenges. Specifically, the grant will fund collaborative research between January 15, 2022 and December 31, 2025 exploring the...
The National Institute of Child Health and Human Development (NICHD) awarded a $451,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the therapeutic potential of maternal breast milk components for preterm white matter injury (WMI). The key objectives are to: 1) Perform high-throughput screening of breast milk components to identify pro-myelinating compounds, and 2) Test...
The National Institute of Child Health and Human Development (NICHD) awarded a $229,968 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Washington. The grant supports a research project to examine the association between adverse maternal factors during pregnancy, such as older age, depression, anemia, HIV infection, and nutritional status, and their impact on human milk oligosaccharides (HMOs) and child...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $246,390 to Cornell University to conduct research on the molecular mechanisms regulating human milk production and composition.
The research aims to elucidate physiological factors contributing to insufficient human milk production, a prevalent issue that leads to early cessation of breastfeeding. The project will utilize the awardee's expertise in molecular biology, in conjunction with clinical studies, to better understand transcriptional regulation of milk production. Key objectives include characterizing the function of a novel gene called C6ORF15, exploring factors influencing infant weight gain, and identifying molecular/cellular mechanisms underlying improved milk production through optimized breast pumping protocols. The results are expected to improve diagnosis and treatment of insufficient milk supply, addressing a significant women's health issue.