This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is funding research to develop accurate prediction models for clinical deterioration in mechanically ventilated children. The $326,160 award will enable the awardee, Ann & Robert H Lurie Children's Hospital of Chicago, to (1) derive and validate longitudinal prediction models that...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $431,750 to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The funding will support a 2-year investigation into the neurobiological mechanisms underlying heterogeneity in social behavior development among young...
The National Institute of Child Health and Human Development (NICHD) awarded The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), a $167,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to study the impact of epigenetic regulation on lung stem cells in congenital lung diseases. The project aims to determine how genetic variants and pharmaceutical interventions affect the differentiation and self-renewal of...
This $133,401 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), seeks to develop computational models that can identify the sequence of changes cells undergo during differentiation and maturation. The goal is to compare changes in gene expression and chromatin accessibility to understand how these modalities coordinate to drive cellular...
This $178,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to develop an early life phenotyping framework for very preterm infants. The research aims to create 'perinatal phenotypes' by integrating variables such as reason for preterm birth, intrapartum care, and neonatal presentation, and then determine how these phenotypes contribute to...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), part of the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $176,515 to Children's Hospital Los Angeles (CHLA) to investigate the relationship between alveolar dead space and new or progressive multiple organ dysfunction syndrome (NPMODS) in critically ill children. The key objectives are to: Identify the association between alveolar dead space and...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $434,500 to the Research Institute at Nationwide Children's Hospital to develop an interpretable machine learning model that leverages maternal and infant electronic health record data to identify neonates in Level III NICUs who are most likely to benefit from early-life genome...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to validate the performance of the DONATE machine learning model in predicting whether a pediatric patient will die within one hour after terminal extubation. The $286,820 award will also define facilitators and barriers to implementing the DONATE model and test the usability of a clinical decision...
This $161,500 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant is intended to establish basic science-clinical collaborations to understand the molecular mechanisms of heterotaxy, a severe form of congenital heart disease that affects 3-4% of patients with congenital heart defects. The funding will support research at the University of Virginia to...
The National Institute of Child Health and Human Development (NICHD) awarded a $261,168 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The objective of this 2-year award is to utilize advanced single-cell multi-omics techniques and machine learning approaches to investigate the cellular heterogeneity, dynamics, and transcriptional regulatory elements associated with multiple organ dysfunction syndrome (MODS) in pediatric patients requiring extracorporeal membrane oxygenation (ECMO) support. The research aims to identify crucial cells and genes linked to MODS deterioration in this patient population, with the goal of developing innovative diagnostic and therapeutic methods for pediatric intensive care unit diseases.