This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), part of the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $176,515 to Children's Hospital Los Angeles (CHLA) to investigate the relationship between alveolar dead space and new or progressive multiple organ dysfunction syndrome (NPMODS) in critically ill children. The key objectives are to:
-
Identify the association between alveolar dead space and NPMODS, adjusting for oxygenation and cardiovascular function.
-
Examine the relationship between markers of microvascular dysfunction and NPMODS and alveolar dead space.
This 2-year project will leverage a cohort of mechanically ventilated children enrolled in an NIH-funded clinical trial, with plasma samples and alveolar dead space measurements collected longitudinally. The goal is to determine if alveolar dead space can serve as an early marker of systemic microvascular dysfunction and NPMODS risk in this high-risk pediatric population. This research has the potential to improve prognostic and predictive enrichment of future clinical trials targeting microvascular dysfunction and NPMODS prevention.
The study also includes a $15,251 sub-award to the University of California, Los Angeles (UCLA) to provide support for the research activities.
Generated 7/16/24, 9:30 AM