Project Grant K99GM166689
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $580,507 on May 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms governing midbody remnants in intercellular RNA communication. Over the five-year period of performance through February 28, 2031, the research will characterize the molecular cargo of midbody remnants—large extracellular vesicles released during cell division—across diverse...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $124,929 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on how epithelial architecture regulates amoeboid migration strategies in vivo. The research examines cell migration through tissues, with focus on leukocyte movement within epithelial layers. Work uses intravital imaging in zebrafish to characterize how mechanical confinement drives...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $412,201 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how metabolic microenvironments direct immune cell plasticity and function. The research project develops and applies an organotypic array for culture in live-cell environments (ORACLE), a micropatterned 3D hydrogel platform with functional vasculature that enables spatial and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $686,308 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how microtubule- and actomyosin-based cytoskeletal networks are spatially regulated during cell division and development. The research integrates experiments in C. elegans embryos and cultured human cells, focusing on centrosomes and their role as microtubule-organizing centers. Work...
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $152,600 on September 30, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of genomic organization by leveraging genetic divergence in Drosophila embryos. The research will determine how the nucleus partitions active and inactive chromatin compartments during early embryogenesis, focusing on the transcription factor GAGA factor (GAF). The...
- The National Institute of General Medical Sciences awarded $429,203 to the University of Wisconsin–Madison on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R35GM161252) to develop optically enhanced NMR methods for high-resolution analysis of biomolecular structure, dynamics, and interactions at sub-micromolar sensitivity under physiologically relevant conditions. The award supports integrated research combining NMR method...
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $413,001 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational systems for analyzing single-cell and spatial transcriptomics experiments. The recipient will create computational methods to improve downstream analysis of gene-expression data from single-cell and spatial transcriptomics experiments, which measure genome-wide expression in...
- The National Institute of General Medical Sciences awarded The Regents of the University of Colorado $426,262 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct computational modeling and measurement of mitotic spindle length control, stability, and elongation. Work is performed in Boulder, Colorado through March 31, 2030. The project identifies mechanisms by which force and biochemistry regulate metaphase spindle length and stability, and...
- The National Institute of General Medical Sciences (NIGMS) awarded the University of Wisconsin–Madison $415,360 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the roles of giant STARSHIP transposons in fungal horizontal gene transfer and evolution. The award funds research to understand how STARSHIP transposons—a newly identified class of giant transposons carrying dozens of genes encoding fungal traits such as secondary metabolite...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $249,000 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate TULP3 protein function in primary cilia signaling and ciliogenesis. The research addresses defects in primary cilia—cellular signaling hubs that sense extracellular signals including odorants, metabolites, light, and neurotransmitters—which are linked to developmental disorders,...
The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $111,290 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research into the mechanisms of spindle position control by cortical CDC42 waves. The research investigates how the small GTPase CDC42 controls mitotic spindle positioning and orientation of the cell division plane, processes essential for proper tissue morphogenesis, development, and cell fate determination. The project builds on preliminary data showing that CDC42 appears in propagating cortical waves during spindle positioning in Xenopus embryos and that suppression of these waves results in inappropriately positioned spindles. The work will clarify CDC42 dynamics during spindle positioning, particularly in vertebrates, where CDC42's role remains poorly understood despite its repeated implication across multiple organisms and tissues. Elucidating this mechanism addresses a long-standing question in developmental biology, as the "default" spindle positioning mechanism—wherein spindles spontaneously align parallel to the longest cell axis—has been documented for over a century but remains incompletely explained. Period of performance runs from September 1, 2026, through August 31, 2028. Work is performed at Madison, Wisconsin. The award is classified as a Project Grant, an assistance type supporting investigator-initiated biomedical research under NIGMS's mission to advance understanding of biological processes and support disease diagnosis, treatment, and prevention advances.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $111.3k | 8/24/26 |