Project Grant K99GM164719
- Federal Grant Award Summary Weill Medical College of Cornell University received a $471,690 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through February 28, 2031. The research initiative focuses on discovering and elucidating the mechanisms of lipid scramblases—specialized proteins that catalyze the translocation of polar lipids across membrane bilayers. This...
- Federal Project Grant Award Summary Cornell University was awarded $380,262 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to develop theoretical and computational methods for investigating redox processes in biological systems. The project, initiated August 1, 2025, and concluding July 31, 2030, will deliver a simulation toolbox utilizing path integral quantum mechanics formulations to characterize electron...
- Federal Grant Award Summary Cornell University received a $380,785 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 15, 2025, with completion targeted for August 31, 2030. The award supports research to develop novel algorithms and computational methods for quantitatively recovering biomolecular structural ensembles from cryogenic electron microscopy (cryo-EM) data. The...
- Federal Grant Award Summary Award Details: Cornell University's Office of Sponsored Programs received a $305,208 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award supports fundamental research into ubiquitin mechanisms in cellular health and pathogen-host interactions, a critical area of investigation given ubiquitination's central role...
- Federal Grant Award Summary Cornell University received a $291,491 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through January 31, 2031. The award supports fundamental research focused on understanding autolysin function in gram-negative bacterial growth and morphogenesis. Specifically, the research aims to elucidate how endopeptidases (EPs) and lytic...
- Federal Grant Award Summary Cornell University's Office of Sponsored Programs received a $428,202 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through May 31, 2030. The award supports fundamental research into the mechanisms of robustness in organogenesis, specifically investigating how developing organs achieve consistent size and shape despite cellular...
- Federal Grant Award Summary Cornell University's Office of Sponsored Programs received a $431,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through July 31, 2030. The award supports fundamental research on intercellular communication mechanisms that govern tissue and organ regeneration. The project will advance understanding of how endogenous and...
- Federal Project Grant Award Summary Cornell University's Office of Sponsored Programs received a $397,022 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through May 31, 2030. The award funds research to establish culture conditions for uncultured microbes, with particular focus on developing the first axenic culture of Wolbachia, an intracellular bacterium...
- Federal Project Grant Award Summary Cornell University's Office of Sponsored Programs received a $2,070,575 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) on August 15, 2025, with completion anticipated by July 31, 2029. This R35 Maximizing Investigators' Research Award funds fundamental research to decipher the cellular origins and toxicological impact of endogenous formaldehyde in mammalian...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $411,250 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, with completion targeted for July 31, 2030. This award funds fundamental biomedical research investigating the molecular composition and functional interactions between membrane-bound...
Cornell University received a $125,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 1, 2026, with completion targeted for April 30, 2028. The research project, conducted at Cornell's Ithaca, New York campus, focuses on decoding inter-organelle phospholipid transport through innovative fluxome profiling methodology. The principal research deliverable involves developing a comprehensive method to directly measure and profile phospholipid transport between cellular organelles without introducing perturbative tags that would disrupt native lipid behavior. The research employs advanced analytical techniques to achieve this objective, including phospholipase D (PLD)-mediated pulse-chase labeling to create deuterated phosphatidylcholine markers and stimulated Raman scattering (SRS) imaging to track phospholipid distribution. A key research product is the creation of a "lipoprint map" that classifies organelles based on lipid-derived SRS spectral fingerprints, which will be integrated with transport data to generate a comprehensive fluxome profile mapping inter-organelle relationships defined by lipid composition and dynamics. The research aims to extend this methodology to additional phospholipid classes through engineered PLD variants, advancing fundamental understanding of cellular phospholipid transport mechanisms under normal physiological conditions and in response to cellular stress.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 5/5/26 |