This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $550,108 to the University of California, Merced to conduct research on the genetic regulation of microbial community formation, particularly in the context of biofilms. The research aims to enhance understanding of how transcriptional networks regulate gene expression during biofilm development, including in fungi,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $305,208 to Cornell University to conduct research on the ubiquitin mechanism in normal cell physiology and pathogen-host interactions. The research aims to elucidate the molecular mechanisms of adaptor-mediated ubiquitination by NEDD4 family E3 ligases, as well as investigate how the intracellular bacterial pathogen Legionella...
This $376,301 project grant awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Rochester aimed at developing a practical approach for controlling and stabilizing microbial communities. The project leverages plasmid conjugation to dynamically balance microbial growth rates and composition, creating programmable microbial populations that can maintain stability across diverse conditions. Key objectives include computational...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund research to characterize the molecular mechanisms and evolution of cyclic diguanylic acid (c-di-GMP) signaling in the antibiotic-producing bacterial genus Streptomyces. The $383,746 award, with a performance period from January 1, 2025 to December 31, 2029, will be executed by Cornell University's Office of Sponsored...
This federal Project Grant award of $854,736, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a comprehensive suite of statistical tools for analyzing longitudinal microbiome studies. The key products and services to be delivered include: Methods for addressing batch effects in longitudinal microbiome data, which is a critical issue as studies grow larger or integrated. Improved...
Cornell University was awarded a $1,317,788 project grant from the National Science Foundation Division of Integrative Organismal Systems to develop tools for host-microbiome protein-protein interaction discovery and establish sequencing-compatible ultra-high-throughput experimental screening approaches. The grant also supports the launch of annual bioinformatics hackathons for students centered on protein structure-inspired projects and the development of computational tools to assign...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
The National Institute of General Medical Sciences (NIGMS) has awarded a $492,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Princeton University. The grant, which runs from Sep 1, 2024 to Aug 31, 2029, supports research aimed at accessing previously hidden sources of microbial natural products and investigating their structures, functions, therapeutic uses, and biosynthetic pathways. Key objectives include eliciting cryptic metabolites from...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $395,701 to the University of Texas at Austin to investigate the molecular bases of interactions between bacteria and their hosts within microbial communities. The research aims to better understand how microbial communities are shaped and how they affect their hosts, using insect models like bees and Drosophila. Key...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $659,230.00 to Cornell University over the period of September 1, 2024 to June 30, 2028. The grant supports research to define how the CymA protein in the gram-negative bacterium Shewanella oneidensis coordinates spatially and temporally with its redox partners to mediate efficient extracellular electron transfer (EET)...