Project Grant K99GM163041
- The National Institute of General Medical Sciences, a division of the Department of Health and Human Services, awarded Cornell University $390,966 on June 1, 2026, as a Project Grant (CFDA 93.859, Biomedical Research and Research Training) to support research on the roles of the epitranscriptome in tailoring gene expression systems. The recipient will uncover the chemical structure, modifying enzymes, and functions of unique tRNA modifications across various organisms, and investigate how...
- The National Institute of General Medical Sciences awarded Cornell University $424,158 on July 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of the Kumgang/MI-2 chromatin remodeling complex and its role in transcriptional fidelity. The research will characterize how tissue-specific zinc finger proteins (ZFPs) interact with the chromatin remodeler MI-2 to repress inappropriate gene transcription. The project will...
- The National Institute of General Medical Sciences awarded Cornell University $277,649 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how DNA topology, R-loop formation, and transcriptional-replicational conflicts regulate gene expression and genome stability. The research employs in vitro and in vivo techniques—biochemical, single-molecule, and genomics methods—to elucidate the mechanistic interplay between DNA torsional stress...
- The National Institute of General Medical Sciences awarded Weill Medical College of Cornell University $226,404 on August 9, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on the structural determination of TrkB assembly and activation. The research investigates the assembly, structure, and conformational dynamics of tropomyosin kinase receptor B (TrkB), a neuronal integral membrane receptor implicated in neurodegenerative, psychiatric, and...
- The National Institute of General Medical Sciences awarded $471,690 to Weill Medical College of Cornell University on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the discovery and mechanism of lipid scramblases — proteins that catalyze the translocation of polar lipids across cell membrane bilayers. The research addresses fundamental questions about scramblase molecular identity, mechanisms of action, physiological contributions, and...
- This $868,584 Project Grant, awarded September 1, 2025, by the National Institute of General Medical Sciences through its Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research investigating how ribonucleic acid (RNA) modifications regulate adaptive messenger RNA (mRNA) translation. The University of Texas Health Science Center at Houston will conduct a two-year research initiative (through August 31, 2027) focused on elucidating the roles of TRMT1L, a...
- The National Institute of General Medical Sciences awarded Cornell University $118,457 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and evolutionary mechanisms of ribonucleotide reductases and squalene cyclases using synthetic chemistry, biochemistry, structural biology, and phylogenetic analysis. This is a K99/R00 mentored career transition award (Project Grant K99GM166683). In the K99 mentored phase, the investigator...
- The National Institute of General Medical Sciences awarded Cornell University $375,154 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to uncover the structure and function of understudied membrane proteins implicated in human disease. The research employs C. elegans as a model organism to systematically examine protein structure, interactome, expression patterns, and associated animal behavior. Over the five-year performance period (through February...
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $462,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance spatial imaging frameworks that reveal how non-coding RNAs organize within the nucleus across developmental and environmental contexts. The research establishes three interconnected themes. Theme 1 extends RNA MERFISH to profile small non-coding RNAs by incorporating enzymatic...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $426,250 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to probe translation regulation by imaging single protein-mRNA interactions in live cells. The research project establishes systems to visualize single protein-RNA interactions in live cells and refines single-molecule translation assays to correlate protein binding with translation dynamics. The work...
The National Institute of General Medical Sciences awarded Weill Medical College of Cornell University $118,751 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis and physiological impact of mRNA 5' nucleotide expansion. The award funds research defining how mRNA 5' expansion—a previously unrecognized transcriptional phenomenon in which additional A and U nucleotides are incorporated near transcript 5' ends in a regulated manner—alters RNA-binding protein interactions and influences translation. The work focuses on elucidating mechanisms through which mRNA 5' expansion modulates terminal oligopyrimidine mRNA translation, a transcript subset regulated by the mTOR pathway and linked to cell growth and cancer. Research activities include proximity labeling to characterize how 5' expansion alters interactions between cap-proximal RNA-binding proteins and mRNA, investigation of UTP metabolism's role in regulating 5' expansion, and integration of nucleotide mass spectrometry and transcriptome-wide 5' mapping techniques. Performance is scheduled through August 31, 2028, at Weill Medical College's New York, New York location. The award carries the Project Grant assistance type and represents the K99 phase of structured research development funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $118.8k | 8/17/26 |